ArticleRenal failure2025
Analysis of potential targets of 20S-protopanaxadiol on diabetic nephropathy based on network pharmacology, molecular docking, and experimental validation.
Article in Renal failure, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- Integrative Network Pharmacology and Molecular Docking Analysis Reveals the Multitarget Mechanisms of Pterostilbene in Neurodegenerative Diseases.Pharmaceuticals (Basel, Switzerland) · 2026Article
- A review of pharmacological properties and pharmacokinetic of 20(S)-protopanaxadiol.Journal of ginseng research · 2026Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThis study aims to investigate the protective effects and mechanisms of 20S-protopanaxadiol (PPD), a key component derived from ginseng folium, against diabetic nephropathy (DN).
methodsIngredients of ginseng folium were collected and screened using the TCMSP database. Therapeutic target genes for ginseng folium against DN were obtained, and protein-protein interaction (PPI) networks were constructed. Gene Ontology (GO) function and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichments were conducted on these targets. Furthermore, the results of network pharmacology were validated
resultsA total of 246 target genes for ginseng folium against DN were identified. KEGG analysis revealed significant enrichment in AGE-RAGE signaling in diabetic complications, PI3K-AKT, MAPK, and TNF pathways. PPD intragastric administration improved renal function in db/db mice and significantly reduced the expression of TGF-β1, α-SMA, p-Smad3, and Smad4 in renal tissue (
conclusionPPD potentially alleviates renal fibrosis in db/db mice and HK-2 cells by inhibiting the TGF-β1/Smads pathway, thereby delaying DN progression.
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Registered trials
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