Evidence map›Paper›PMID 40957871›Full record

ArticleNature communications2025

Gray matter correlates of childhood maltreatment lack replicability in a multi-cohort brain-wide association study.

Janik Goltermann, Nils R Winter, Susanne Meinert, Dominik Grotegerd, Anna Kraus, Kira Flinkenflügel, Luisa Altegoer, Judith Krieger, Elisabeth J Leehr, Joscha Böhnlein and 22 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

32 authors.

Janik GoltermannInstitute for Translational Psychiatry, University of Münster, Münster, Germany. janik.goltermann@gmail.com.ORCID http://orcid.org/0000-0003-3087-1002
Nils R WinterInstitute for Translational Psychiatry, University of Münster, Münster, Germany.ORCID http://orcid.org/0000-0002-6241-1492
Susanne MeinertInstitute for Translational Psychiatry, University of Münster, Münster, Germany.ORCID http://orcid.org/0000-0003-2177-7161
Dominik GrotegerdInstitute for Translational Psychiatry, University of Münster, Münster, Germany.
Anna KrausInstitute for Translational Psychiatry, University of Münster, Münster, Germany.ORCID http://orcid.org/0000-0003-2627-4563
Kira FlinkenflügelInstitute for Translational Psychiatry, University of Münster, Münster, Germany.ORCID http://orcid.org/0000-0001-7738-5429
Luisa AltegoerInstitute for Translational Psychiatry, University of Münster, Münster, Germany.
Judith KriegerInstitute for Translational Psychiatry, University of Münster, Münster, Germany.
Elisabeth J LeehrInstitute for Translational Psychiatry, University of Münster, Münster, Germany.
Joscha BöhnleinInstitute for Translational Psychiatry, University of Münster, Münster, Germany.ORCID http://orcid.org/0000-0002-9870-5599
Linda M BonnekohInstitute for Translational Psychiatry, University of Münster, Münster, Germany.
Maike RichterInstitute for Translational Psychiatry, University of Münster, Münster, Germany.
Tim HahnInstitute for Translational Psychiatry, University of Münster, Münster, Germany.ORCID http://orcid.org/0000-0001-6541-3795
Lukas FischInstitute for Translational Psychiatry, University of Münster, Münster, Germany.
Marius GruberInstitute for Translational Psychiatry, University of Münster, Münster, Germany.
Marco HermesdorfInstitute of Epidemiology and Social Medicine, University of Münster, Münster, Germany.
Klaus BergerInstitute of Epidemiology and Social Medicine, University of Münster, Münster, Germany.
Volker AroltInstitute for Translational Psychiatry, University of Münster, Münster, Germany.ORCID http://orcid.org/0000-0002-2445-9778
Katharina BroschDepartment of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany.
Frederike SteinDepartment of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany.
Florian Thomas-OdenthalDepartment of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany.ORCID http://orcid.org/0000-0003-4912-8307
Paula UsemannDepartment of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany.
Lea TeutenbergDepartment of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany.
Vincent HammesDepartment of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany.
Hamidreza JamalabadiDepartment of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany.ORCID http://orcid.org/0000-0003-2485-2374
Nina AlexanderDepartment of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany.
Benjamin StraubeDepartment of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany.ORCID http://orcid.org/0000-0002-9837-0944
Andreas JansenDepartment of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany.
Igor NenadićDepartment of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany.ORCID http://orcid.org/0000-0002-0749-7473
Tilo KircherDepartment of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany.ORCID http://orcid.org/0000-0002-2514-2625
Nils Opel *Department of Psychiatry and Neuroscience, Campus Benjamin Franklin, Charité-Universitätsmedizin Berlin, Berlin, Germany.ORCID http://orcid.org/0000-0003-4749-3298
Udo Dannlowski *Institute for Translational Psychiatry, University of Münster, Münster, Germany.ORCID http://orcid.org/0000-0002-0623-3759

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Childhood maltreatment effects on cerebral gray matter have been frequently discussed as a neurobiological pathway for depression. However, localizations are highly heterogeneous, and recent reports have questioned the replicability of mental health neuroimaging findings. Here, we investigate the replicability of gray matter correlates of maltreatment, measured retrospectively via the Childhood Trauma Questionnaire, across three large adult cohorts (total N = 3225). Pooling cohorts yields maltreatment-related gray matter reductions, with most extensive effects when not controlling for depression diagnosis (maximum partial R

Indexed as

Adult Survivors of Child AbuseBrainChild AbuseGray MatterAdultChildCohort StudiesDepressionFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedNeuroimagingRetrospective StudiesSurveys and Questionnaires

Identifiers

PMID40957871
PMCPMC12441139

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.