ReviewMolecular therapy : the journal of the American Society of Gene Therapy2025
Epigenetic mechanisms of HIV and opioid-induced neuropathology: Potential therapies and interventions.
Review in Molecular therapy : the journal of the American Society of Gene Therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Periodontitis-Induced Immune Reprogramming: Implications for Cancer Immunotherapy Response.Biomedicines · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
HIV continues to be a significant global health issue, especially regarding its connection to the opioid epidemic. Substance abuse heightens the risk of spreading HIV infection and is linked to treatment non-compliance, accelerated disease progression, and increased mortality. Recent studies link epigenetic changes with the emergence of opioid addiction and neurodegenerative diseases. Despite new insights, the lasting epigenetic effects of opioid abuse on the severity, progression, and outlook of HIV-associated neurocognitive disorders (HAND) remain unclear. HAND occurs even with adequate antiretroviral therapy, for which there are currently no effective treatments. The epigenome in the central nervous system (CNS) plays a crucial role in helping humans adapt to a changing environment, and its dysregulation can lead to various CNS disorders; however, the underlying mechanisms of such developments are poorly understood. At present, several epigenetic drugs are being developed and tested in clinical trials as supplemental therapies for CNS disorders, including age-related neurodegeneration, mood disorders, and behavioral disorders. Accumulated evidence suggests that future therapeutic strategies should prioritize the development of epigenetic drugs, or epidrugs, as adjunct therapies for treating CNS disorders, including HAND and addiction-related diseases. This review explores the epigenetic mechanisms governing HIV-related neurological impairment amid the influence of opioid abuse.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.