Evidence mapPaperPMID 40958765Full record

ReviewAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Biodegradable Zinc-Based Alloys for Guided Bone Regeneration Membranes: Feasibility, Current Status, and Future Prospects.

Kai Chen, Ping Li, Qiang Guan, Xuenan Gu, Li Zhao, Linjun Huang, Chenyang Huang, Yu Qin, Chunhao Yu, Ting Zhang and 3 more

Abstract readReview
In one paragraph

Review in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Thermally Induced Creep and Viscoelastic Behavior of Copper Micropillar Arrays.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Kai ChenSchool of Materials Science and Engineering, Peking University, Beijing, 100871, China.
Ping LiDepartment of Third Dental Center, Peking University School and Hospital of Stomatology, Beijing, 100191, China.
Qiang GuanShenzhen Engineering Laboratory of Orthopaedic Regenerative Technologies, Department of Spine Surgery, Peking University Shenzhen Hospital, Shenzhen Peking University-The Hong Kong University of Science and Technology Medical Center, Shenzhen, Guangdong Province, 518036, China.
Xuenan GuKey Laboratory of Biomechanics and Mechanobiology (Beihang University), Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing, 100083, China.
Li ZhaoInstitute for Advanced Materials and Technology, University of Science and Technology Beijing, Beijing, 100083, China.
Linjun HuangShenzhen Engineering Laboratory of Orthopaedic Regenerative Technologies, Department of Spine Surgery, Peking University Shenzhen Hospital, Shenzhen Peking University-The Hong Kong University of Science and Technology Medical Center, Shenzhen, Guangdong Province, 518036, China.
Chenyang HuangKey Laboratory of Biomechanics and Mechanobiology (Beihang University), Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing, 100083, China.
Yu QinSchool of Materials Science and Engineering, Peking University, Beijing, 100871, China.
Chunhao YuSchool of Life, Beijing Institute of Technology, No. 5, Zhongguancun South Street, Haidian District, Beijing, 100081, China.
Ting ZhangSchool of Materials Science and Engineering, Peking University, Beijing, 100871, China.
Hejia LiDepartment of Third Dental Center, Peking University School and Hospital of Stomatology, Beijing, 100191, China.
Yongcan HuangSchool of Materials Science and Engineering, Peking University, Beijing, 100871, China.
Yufeng ZhengSchool of Materials Science and Engineering, Peking University, Beijing, 100871, China.ORCID https://orcid.org/0000-0002-7402-9979

Funding

Guangdong Basic and Applied Basic Research Foundation 2023A1515110522Guangdong Basic and Applied Basic Research Foundation 2023A1515220095Guangdong Basic and Applied Basic Research Foundation 2025A1515010860National Key Research and Development Program of China 2022YFA1206101National Natural Science Foundation of China 52401304National Natural Science Foundation of China 52471257National Natural Science Foundation of China U22A20121Shenzhen Science and Technology Program GJHZ20210705142543019Shenzhen Science and Technology Program KJZD20230923113959013
6 · The paper itself

Abstract

The guided bone regeneration (GBR) technique is an effective method for treating inadequate alveolar ridge bone mass. The choice of barrier membrane materials plays a crucial role in the success of this technique. Recently, biodegradable zinc (Zn)-based metallic barrier membranes have been extensively investigated as a novel option for alveolar bone defect repair. Although in vitro and animal studies using Zn-based GBR membranes have shown some promising results, it remains uncertain whether these successes can be replicated in humans. In this review article, the clinical requirements for GBR membranes are discussed and the feasibility of Zn-based alloys as a potential new option is assessed. Current advancements in the development of Zn-based GBR membranes through alloying, surface modification, composite methods, and additive manufacturing techniques are also summarized. Importantly, several challenges persist, including stress corrosion, creep, and the need to balance osteogenesis with antimicrobial efficacy, which must be addressed in future studies. Overall, Zn-based barrier membranes represent a biodegradable and multifunctional solution for enhancing bone regeneration in dental applications.

Indexed as

Absorbable ImplantsAlloysBiocompatible MaterialsBone RegenerationGuided Tissue RegenerationGuided Tissue Regeneration, PeriodontalMembranes, ArtificialZincAnimalsHumansAlloysBiocompatible MaterialsMembranes, ArtificialZincbiodegradable zinccurrent statusfeasibilityfuture prospectsguided bone regeneration (GBR) membrane

Identifiers

PMID40958765
PMCPMC12561286

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.