ArticleMayo Clinic proceedings. Innovations, quality & outcomes2025
Greater Central Adiposity Is Associated With Poorer Left Atrial Function: The Atherosclerosis Risk in Communities (ARIC) Study.
Article in Mayo Clinic proceedings. Innovations, quality & outcomes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
Objective: To evaluate the association of longitudinal change in waist circumference (WC), waist-to-hip ratio (WHR), and body mass index (BMI) with left atrial (LA) function in the Atherosclerosis Risk in Communities study, a community-based cohort study. Patients and Methods: We included 4008 participants (mean age, 75.1 years; 59% female; 20% Black) with 2D speckle-tracking echocardiographic LA strain data and without prevalent heart failure or atrial fibrillation at visit (V)5. Measures of adiposity were obtained at V4 (1996-1998) and V5 (2011-2013). We categorized change in WC, BMI, or WHR from V4 to V5 as consistently low (reference group), consistently elevated, increasing, and decreasing. Multivariable linear regression was used to evaluate the association of change in adiposity with LA function. Results: Participants with consistently elevated WC from V4 to V5 had the lowest mean LA reservoir (32.4%) and conduit function (14.4%). Compared with consistently low WC, increasing WC and consistently elevated WC were significantly associated with worse LA reservoir function ( Conclusion: Worsening central adiposity from mid-life to late life is associated with reduced LA reservoir and conduit function, independent of LA size and LV size and function. This finding underscores the key role that consistently low adiposity might play in preventing atrial myopathy.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.