Evidence map›Paper›PMID 40959084›Full record

ReviewFrontiers in immunology2025

Personalised immunotherapy strategies informed by single cell profiling in thyroid cancer: a mini review.

Ruyu Chen, Zhimin Wang, Xueying Chen, Yangling Huang, Fengnuan Zhang, Tianshu Gao

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ruyu Chen *First Clinical College, Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning, China.
Zhimin Wang *Department of Endocrinology,The First Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning, China.
Xueying ChenDepartment of Endocrinology,The First Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning, China.
Yangling HuangFirst Clinical College, Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning, China.
Fengnuan ZhangDepartment of Endocrinology,The First Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning, China.
Tianshu GaoDepartment of Endocrinology,The First Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Thyroid cancer (TC) is now among the fastest-growing solid tumours, yet therapeutic gains remain limited for poorly differentiated, anaplastic and medullary variants whose median survivals are measured in months. Once guided chiefly by histology and single-gene assays, immunotherapy is being reshaped by single-cell profiling, which exposes the cellular mosaics that arbitrate response and resistance. Dissection of more than 150-000 tumour- and immune-cell transcriptomes has uncovered follicular-like, partial EMT-like and dedifferentiated thyrocyte states embedded within 'hot' (CD8

Indexed as

ImmunotherapyPrecision MedicineSingle-Cell AnalysisThyroid NeoplasmsAnimalsHumansTranscriptomeTumor Microenvironmentimmune checkpoint blockademacrophage reprogrammingsingle-cell RNA-sequencingspatial transcriptomicsthyroid cancertumour microenvironment

Identifiers

PMID40959084
PMCPMC12434061

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.