ReviewFrontiers in physiology2025
Electrophysiological and biophysical perspectives on the clitoral corpus cavernosum and its role in female sexual arousal disorder.
Review in Frontiers in physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The clitoris is a vital part of the female sexual system, playing a crucial role in sexual satisfaction and overall sexual health. During arousal, the smooth muscle within the corpus cavernosum of the clitoris relaxes, which increases blood flow and causes the clitoral tissues to swell and firm. This vascular engorgement is not only essential for clitoral erection but also enhances the pleasurable sensations during sexual activity. However, conditions such as pelvic floor disorders, Peyronie's disease, neuromuscular disorders, and hormonal imbalances can lead to dysfunction in the smooth muscle of the corpus cavernosum, significantly impacting female sexual function. The contractile behavior of these smooth muscles is governed by intricate cellular and subcellular processes, particularly the generation of intracellular electrical activities, with calcium influx playing a central role. This calcium influx is mediated through voltage-dependent calcium channels and calcium release from intracellular stores. Despite the critical importance of these mechanisms, comprehensive studies on the biophysical aspects of smooth muscle electrophysiology are limited, likely due to their complexity. This review seeks to investigate the cellular electrophysiological mechanisms underlying the electrical excitability of corpus cavernosum smooth muscle and to understand the biophysical aspects of clitoral muscle contraction disorders. It also proposes a first conceptual model to guide future research, with the aim of supporting the development of more effective treatments and enhancing female sexual health.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.