Evidence map›Paper›PMID 40959204›Full record

ArticleMedComm2025

A Novel Genetic TDP-43 Pig Model Mimics Multiple Key ALS-Like Features.

Chunhui Huang, Xiao Zheng, Jiaxi Wu, Jiawei Li, Yingqi Lin, Yizhi Chen, Caijuan Li, Xichen Song, Wei Wang, Zhaoming Liu and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in MedComm, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Chunhui HuangGuangdong Provincial Key Laboratory of Non-human Primate Research The Sixth Affiliated Hospital of Jinan University, Dongguan, China; Guangdong Provincial Key Laboratory of Non-human Primate Research, Guangdong-Hong Kong-Macau Institute of CNS Regeneration, Jinan University Guangzhou China.
Xiao ZhengDepartment of Periodontology and Oral Implantology Stomatological Hospital School of Stomatology Southern Medical University Guangzhou China.
Jiaxi WuGuangdong Provincial Key Laboratory of Non-human Primate Research The Sixth Affiliated Hospital of Jinan University, Dongguan, China; Guangdong Provincial Key Laboratory of Non-human Primate Research, Guangdong-Hong Kong-Macau Institute of CNS Regeneration, Jinan University Guangzhou China.
Jiawei LiGuangdong Provincial Key Laboratory of Non-human Primate Research The Sixth Affiliated Hospital of Jinan University, Dongguan, China; Guangdong Provincial Key Laboratory of Non-human Primate Research, Guangdong-Hong Kong-Macau Institute of CNS Regeneration, Jinan University Guangzhou China.
Yingqi LinGuangdong Provincial Key Laboratory of Non-human Primate Research The Sixth Affiliated Hospital of Jinan University, Dongguan, China; Guangdong Provincial Key Laboratory of Non-human Primate Research, Guangdong-Hong Kong-Macau Institute of CNS Regeneration, Jinan University Guangzhou China.
Yizhi ChenGuangdong Provincial Key Laboratory of Non-human Primate Research The Sixth Affiliated Hospital of Jinan University, Dongguan, China; Guangdong Provincial Key Laboratory of Non-human Primate Research, Guangdong-Hong Kong-Macau Institute of CNS Regeneration, Jinan University Guangzhou China.
Caijuan LiGuangdong Provincial Key Laboratory of Non-human Primate Research The Sixth Affiliated Hospital of Jinan University, Dongguan, China; Guangdong Provincial Key Laboratory of Non-human Primate Research, Guangdong-Hong Kong-Macau Institute of CNS Regeneration, Jinan University Guangzhou China.
Xichen SongGuangdong Provincial Key Laboratory of Non-human Primate Research The Sixth Affiliated Hospital of Jinan University, Dongguan, China; Guangdong Provincial Key Laboratory of Non-human Primate Research, Guangdong-Hong Kong-Macau Institute of CNS Regeneration, Jinan University Guangzhou China.
Wei WangGuangdong Provincial Key Laboratory of Non-human Primate Research The Sixth Affiliated Hospital of Jinan University, Dongguan, China; Guangdong Provincial Key Laboratory of Non-human Primate Research, Guangdong-Hong Kong-Macau Institute of CNS Regeneration, Jinan University Guangzhou China.
Zhaoming LiuChina-New Zealand Joint Laboratory on Biomedicine and Health CAS Key Laboratory of Regenerative Biology Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine Guangzhou Institutes of Biomedicine and Health Chinese Academy of Sciences Guangzhou China.
Jianhao WuGuangdong Provincial Key Laboratory of Non-human Primate Research The Sixth Affiliated Hospital of Jinan University, Dongguan, China; Guangdong Provincial Key Laboratory of Non-human Primate Research, Guangdong-Hong Kong-Macau Institute of CNS Regeneration, Jinan University Guangzhou China.
Jiale GaoGuangdong Provincial Key Laboratory of Non-human Primate Research The Sixth Affiliated Hospital of Jinan University, Dongguan, China; Guangdong Provincial Key Laboratory of Non-human Primate Research, Guangdong-Hong Kong-Macau Institute of CNS Regeneration, Jinan University Guangzhou China.
Zhuchi TuGuangdong Provincial Key Laboratory of Non-human Primate Research The Sixth Affiliated Hospital of Jinan University, Dongguan, China; Guangdong Provincial Key Laboratory of Non-human Primate Research, Guangdong-Hong Kong-Macau Institute of CNS Regeneration, Jinan University Guangzhou China.
Zaijun ZhangInstitute of New Drug Research College of Pharmacy Jinan University Guangzhou China.
Liangxue LaiChina-New Zealand Joint Laboratory on Biomedicine and Health CAS Key Laboratory of Regenerative Biology Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine Guangzhou Institutes of Biomedicine and Health Chinese Academy of Sciences Guangzhou China.
Shihua LiGuangdong Provincial Key Laboratory of Non-human Primate Research The Sixth Affiliated Hospital of Jinan University, Dongguan, China; Guangdong Provincial Key Laboratory of Non-human Primate Research, Guangdong-Hong Kong-Macau Institute of CNS Regeneration, Jinan University Guangzhou China.
Xiao-Jiang LiGuangdong Provincial Key Laboratory of Non-human Primate Research The Sixth Affiliated Hospital of Jinan University, Dongguan, China; Guangdong Provincial Key Laboratory of Non-human Primate Research, Guangdong-Hong Kong-Macau Institute of CNS Regeneration, Jinan University Guangzhou China.
Sen YanGuangdong Provincial Key Laboratory of Non-human Primate Research The Sixth Affiliated Hospital of Jinan University, Dongguan, China; Guangdong Provincial Key Laboratory of Non-human Primate Research, Guangdong-Hong Kong-Macau Institute of CNS Regeneration, Jinan University Guangzhou China.ORCID https://orcid.org/0000-0003-4889-1570

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease that lacks ideal models to comprehensively recapitulate its pathological features. TDP-43 pathology, a hallmark of neurodegenerative diseases, plays a critical role in disease progression. Given the anatomical and physiological similarities between pig and human brains, large animal models offer a unique advantage in more accurately simulating patient-specific disease characteristics. In this study, we rapidly established a TDP-43-induced neurodegenerative disease model in pigs through ear vein injection of the TDP-43

Indexed as

amyotrophic lateral sclerosisAPOE4movement disorderpig modelSOD1TDP‐43

Identifiers

PMID40959204
PMCPMC12434190

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.