Evidence map›Paper›PMID 40959257›Full record

ArticleACS medicinal chemistry letters2025

Radiosynthesis and Preclinical Evaluation of a Carbon-11 Labeled Phosphodiesterase 7 Inhibitor for PET Neuroimaging.

Zhiwei Xiao, Jiyun Sun, Masayuki Fujinaga, Huiyi Wei, Chunyu Zhao, Achi Haider, Richard Van, Shi Kuang, Tomoteru Yamasaki, Yiding Zhang and 16 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS medicinal chemistry letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Development of a NovelMolecular pharmaceutics · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Zhiwei XiaoDepartment of Radiology, Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, Massachusetts 02114, United States.
Jiyun SunDepartment of Radiology, Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, Massachusetts 02114, United States.
Masayuki FujinagaDepartment of Advanced Nuclear Medicine Sciences, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan.ORCID https://orcid.org/0000-0002-0418-229X
Huiyi WeiCenter of Cyclotron and PET Radiopharmaceuticals, Department of Nuclear Medicine, and PET/CT-MRI Center, The First Affiliated Hospital of Jinan University, Guangzhou 510630, China.
Chunyu ZhaoDepartment of Radiology, Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, Massachusetts 02114, United States.
Achi HaiderDepartment of Radiology, Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, Massachusetts 02114, United States.
Richard VanDepartment of Chemistry and Biochemistry, University of Oklahoma, Norman, Oklahoma 73019, United States.
Shi KuangAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, United States.ORCID https://orcid.org/0000-0003-3520-9499
Tomoteru YamasakiDepartment of Advanced Nuclear Medicine Sciences, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan.ORCID https://orcid.org/0000-0001-7773-3665
Yiding ZhangDepartment of Advanced Nuclear Medicine Sciences, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan.
Jian RongDepartment of Radiology, Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, Massachusetts 02114, United States.ORCID https://orcid.org/0000-0002-3960-1669
Kuan HuDepartment of Advanced Nuclear Medicine Sciences, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan.ORCID https://orcid.org/0009-0004-2549-629X
Jiahui ChenDepartment of Radiology, Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, Massachusetts 02114, United States.ORCID https://orcid.org/0000-0001-9186-1110
Erick Calderon LeonDepartment of Chemistry and Biochemistry, University of Oklahoma, Norman, Oklahoma 73019, United States.
Wakana MoriDepartment of Advanced Nuclear Medicine Sciences, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan.
Lin XieDepartment of Advanced Nuclear Medicine Sciences, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan.
Junjie WeiCenter of Cyclotron and PET Radiopharmaceuticals, Department of Nuclear Medicine, and PET/CT-MRI Center, The First Affiliated Hospital of Jinan University, Guangzhou 510630, China.
Yi XuDepartment of Cardiology, The First Affiliated Hospital of Jinan University, Guangzhou 510630, China.
Yihan ShaoDepartment of Chemistry and Biochemistry, University of Oklahoma, Norman, Oklahoma 73019, United States.ORCID https://orcid.org/0000-0001-9337-341X
Han-Ting ZhangDepartments of Neuroscience, Behavioral Medicine & Psychiatry, Physiology, and Pharmacology, the Rockefeller Neuroscience Institute, West Virginia University Health Sciences Center, Morgantown, West Virginia 26506, United States.
Ying XuDepartment of Anesthesiology, Rutgers, The State University of New Jersey, Newark, New Jersey 07103, United States.
Chongzhao RanAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, United States.
Kc Kent LloydDepartment of Surgery, School of Medicine, and Mouse Biology Program, University of California, Davis, 2795 Second Street, Suite 400, Davis, California 95618, United States.
Lu WangCenter of Cyclotron and PET Radiopharmaceuticals, Department of Nuclear Medicine, and PET/CT-MRI Center, The First Affiliated Hospital of Jinan University, Guangzhou 510630, China.
Ming-Rong ZhangDepartment of Advanced Nuclear Medicine Sciences, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan.ORCID https://orcid.org/0000-0002-3001-9605
Steven H LiangDepartment of Radiology, Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, Massachusetts 02114, United States.ORCID https://orcid.org/0000-0003-1413-6315

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dysfunction of cyclic nucleotide phosphodiesterase 7 (PDE7) has been associated with excess intracellular cAMP concentrations, fueling pathogenic processes that are implicated in neurodegenerative disorders. This study aimed to develop a suitable positron emission tomography (PET) probe that allows noninvasive mapping of PDE7 in the mammalian brain. Based on a spiro cyclohexane-1,4'-quinazolinone scaffold with known inhibitory properties toward PDE7, we designed and synthesized a carbon-11 labeling tolerant methoxy analog. The resulting PET probe, code named [

Indexed as

InhibitorPhosphodiesterase 7Positron emission tomographyQuinazolinone scaffoldRadioligand

Identifiers

PMID40959257
PMCPMC12434536

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.