ArticleCureus2025
Impact of Dentin Pre-treatment Strategies on Colour Stability of Nanohybrid Composite Resin: An In Vitro Spectrophotometric Analysis.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
introductionMatrix metalloproteinases (MMPs) are endogenous dentinal enzymes that remain latent until activated in acidic environments. During self-etch or etch-and-rinse adhesive procedures, activated MMPs degrade the dentin matrix, breaking down type I collagen fibres and thereby compromising the hybrid layer and bond strength. To mitigate this degradation, MMP inhibitors are employed as dentin pre-treatment agents, effectively limiting collagen fibre degradation and enhancing bond strength. MMP inhibitors help preserve the integrity of the adhesive interface between the resin composite and dentin. Chlorhexidine (CHX), a widely used MMP inhibitor, is associated with a potential adverse effect of dental staining. A recently introduced collagen crosslinker, riboflavin, shows promising potential for enhancing bond strength. However, the influence of riboflavin on the colour stability of composite resin has not been evaluated.
aimTo evaluate the effect of various dentin pre-treatment strategies on the colour stability of nanohybrid composite resin.
methodsThirty
resultsThe Kolmogorov-Smirnov test was conducted to evaluate the normality of the data, followed by one-way ANOVA and Tukey's Post-hoc test for multiple pairwise comparisons. The highest mean discolouration was observed in group II (CHX), with a value of 4.09, followed by group III, with a ΔE* value of 3.91. The lowest mean discolouration was observed in group I, with a value of 2.69. Pairwise comparison revealed a statistically significant difference between groups I and II.
conclusionPreserving bond strength without compromising aesthetic outcome is crucial in restorative dentistry. Riboflavin, a collagen crosslinking agent, emerges as a promising alternative. Its potential to stabilise the dentin collagen matrix may enhance the durability of adhesive interfaces while maintaining the optical properties necessary for aesthetic restorations.
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