ArticleFrontiers in medicine2025
Unanticipated discovery: basal metabolic rate as an independent risk factor for metabolic dysfunction-associated steatotic liver disease in a 5-year longitudinal cohort study of non-obese individuals in China.
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Joint assessment of insulin resistance surrogate indices and basal metabolic rate for primary prevention of cardiometabolic multimorbidity: evidence from the China Health and Retirement Longitudinal Study (2011-2020).Cardiovascular diabetology · 2026Article
- A Positive Correlation of Basal Metabolic Rate With Significant Liver Fibrosis in Adults With MASLD and Obesity: Results From NHANES 2017-2020.Canadian journal of gastroenterology & hepatology · 2026Article
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Authors and funding
5 authors.
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Abstract
Objective: The role of basal metabolic rate (BMR) in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) remains controversial, with previous studies yielding inconsistent results. The precise relationship remains poorly understood, particularly in non-obese individuals. This study aimed to investigate the longitudinal association between BMR and incident MASLD in a large, non-obese Chinese cohort. Methods: This longitudinal cohort study included 16,173 non-obese participants free of MASLD at baseline. They were prospectively followed up for 5 years, with the outcome event being the development of MASLD. Participants were divided into quartiles based on their basal metabolic rate (BMR). The association between BMR and incident MASLD was examined using both Cox regression models and restricted cubic spline analysis (RCS). Results: During the 5-year follow-up period, 2,322 non-obese participants developed MASLD. Multivariate Cox regression analysis revealed that after fully adjusting for relevant confounding factors, the BMR was positively associated with incident MASLD, and the risk of MASLD gradually increased with increasing BMR (HR: 1.3, 95% CI: 1.3, 1.4; Conclusion: In this non-obese Chinese cohort, an elevated BMR was identified as an independent risk factor for incident MASLD. This suggests that BMR could be a valuable early biomarker for MASLD risk stratification, even in individuals without obesity.
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