ReviewFrontiers in pharmacology2025
Therapeutic potential of plant-derived natural products against drug-induced liver injury.
Review in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- The potential effects, mechanisms and translational perspectives of natural products in the treatment of atopic dermatitis.Chinese medicine · 2026Review
- Casticin Alleviates Acetaminophen-Induced Acute Liver Injury by Modulating the TLR4/MyD88/TRAF6/NF-κB Signaling Pathway.Pharmaceuticals (Basel, Switzerland) · 2026Article
- Tripterygium Glycosides Extract-Induced Hepatic Cholestasis: A Mechanistic Study Using a Microfluidic Liver-on-a-Chip System.International journal of molecular sciences · 2026Article
- Oxidative Stress and Antioxidant Defense During Liver Regeneration After Acetaminophen Toxicity: The Preventive Potential of the MicroalgaAntioxidants (Basel, Switzerland) · 2026Article
- Quercetin alleviates rifampicin-induced hepatocyte injury by modulating the Hippo-YAP signaling pathway.Frontiers in medicine · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Drug-induced liver injury (DILI) is a major cause of drug development failure and post-marketing restrictions. To date, over 1,000 drugs have been reported to cause liver damage, such as acetaminophen, isoniazid, methotrexate, triptolide and so on. However, there are currently no effective therapies for DILI. Plant-derived natural products including flavonoids, phenylpropanoids, terpenoids, and glycosides have been used for the treatment of DILI due to their low toxicity and strong bioactivity. These anti-DILI compounds involve multiple mechanisms, such as reducing oxidative stress and inflammation, restoring mitochondrial function, and suppressing apoptosis. This review primarily summarizes the recent advances over the past 5 years in the therapeutic potential of natural products against a range of commonly used hepatotoxic drugs rather than focusing on a specific hepatotoxic agent. The insights will provide a cue for further research and promote the development of novel and effective drugs for treating DILI.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.