Evidence map›Paper›PMID 40959459›Full record

ArticleMedComm2025

Single-Cell Transcriptomic Atlas of Peripheral Blood Reveals B-Cell-Driven Signature Predictive of Acute Pancreatitis Severity.

Rongli Xie, Guohui Xiao, Kaige Yang, Xiaofeng Wang, Cong Chen, Min Ding, Tong Zhou, Rajarshi Mukherjee, Robert Sutton, Erzhen Chen and 4 more

Erratum issuedAbstract read
In one paragraph

Article in MedComm, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Rongli XieDepartment of General Surgery RuiJin Hospital Lu Wan Branch Shanghai Jiao Tong University School of Medicine Shanghai China.ORCID https://orcid.org/0000-0002-5266-383X
Guohui XiaoDepartment of General Surgery Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China.
Kaige YangDepartment of General Surgery Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China.
Xiaofeng WangDepartment of Emergency Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China.
Cong ChenDepartment of General Surgery Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China.
Min DingDepartment of General Surgery RuiJin Hospital Lu Wan Branch Shanghai Jiao Tong University School of Medicine Shanghai China.
Tong ZhouDepartment of Pediatrics Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China.
Rajarshi MukherjeeLiverpool EmerGenT Academy Department of Emergency General and Major Trauma Surgery Aintree University Hospital Liverpool University Hospitals NHS Foundation Trust Liverpool UK.
Robert SuttonInstitute of Systems Molecular & Integrative Biology University of Liverpool Liverpool UK.
Erzhen ChenDepartment of Emergency Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China.
Ying ChenDepartment of Emergency Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China.
Wei HuangWest China Centre of Excellence for Pancreatitis Institute of Integrated Traditional Chinese and Western Medicine West China-Liverpool Biomedical Research Centre West China Hospital Sichuan University Chengdu China.
Dan XuDepartment of Emergency Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China.
Jian FeiDepartment of General Surgery RuiJin Hospital Lu Wan Branch Shanghai Jiao Tong University School of Medicine Shanghai China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Effective early prediction of acute pancreatitis (AP) severity remains an unmet clinical need due to limited molecular characterization of systemic immune responses. We performed integrated single-cell RNA sequencing with T- and B-cell receptor profiling on peripheral blood mononuclear cells from AP patients (

Indexed as

acute pancreatitisB cellsmachine learningmolecular biomarkerseverity prediction

Identifiers

PMID40959459
PMCPMC12434316

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.