ArticleFood science & nutrition2025
Coaxial Electrospraying for Black Seed Oil Nanoencapsulation: Improved Thymoquinone Stability and Bioactivity.
Article in Food science & nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Thymoquinone is the primary bioactive compound in black seed oil (BSO), but it has limited stability under harsh conditions. Nanoencapsulation using zein via coaxial electrospraying is an effective approach to improve its stability and bioactivity during gastrointestinal transit. Therefore, this study aimed to develop BSO-loaded nanoparticles using coaxial electrospraying, evaluate their stability at different temperatures (4°C, 25°C and 60°C), and investigate their in vitro bioaccessibility, intestinal permeability using Caco-2 cell models, and immunomodulatory potential. Nanoparticles with high encapsulation efficiency (74.38% ± 2.6%) and loading capacity (12.99% ± 3.6%) retained thymoquinone content at 91.3%, 74.7%, and 52.0% after 55 days of storage at 4°C, 25°C, and 60°C, respectively. The bioaccessibility of thymoquinone in nanoparticles increased from 21.7% to 33.1% when orange juice was fortified with nanoparticles. The apparent permeability of thymoquinone in nonencapsulated oil, nanoparticles, and orange juice fortified with nonencapsulated oil and nanoparticles was 2.10 × 10
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