Evidence map›Paper›PMID 40959587›Full record

ReviewInternational journal of general medicine2025

Molecular Aspects of Mitochondrial Dysfunction in Diabetes, Pearson and Kearns-Sayre Syndromes, and Neurodegenerative Disorders.

Amirmohammad Shafiee, Amir Ali Akhlaghi, Abigail Ellstrom, Seyed Omid Mohammadi, Alimohammad Shafiee, Mohanakrishnan Sathyamoorthy

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of general medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Amirmohammad ShafieeSathyamoorthy Laboratory in Department of Internal Medicine, Burnett School of Medicine at Texas Christian University, Fort Worth, TX, USA.
Amir Ali AkhlaghiSchool of Biomedical Engineering, McMaster University, Hamilton, ON, Canada.
Abigail EllstromSathyamoorthy Laboratory in Department of Internal Medicine, Burnett School of Medicine at Texas Christian University, Fort Worth, TX, USA.
Seyed Omid MohammadiBurnett School of Medicine at Texas Christian University, Fort Worth, TX, USA.
Alimohammad ShafieeDepartment of Family Medicine, Kelvington Hospital, Kelvington, SK, Canada.
Mohanakrishnan SathyamoorthySathyamoorthy Laboratory in Department of Internal Medicine, Burnett School of Medicine at Texas Christian University, Fort Worth, TX, USA.ORCID 0000-0003-1686-9264

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mitochondrial dysfunction results in complex pathophysiological alterations associated with clinical disease states including cancer, cardiovascular diseases, diabetes mellitus, and anxiety disorders. As a key organelle within mammalian cells, the mitochondrion serves as the energetic source of cellular function which are crucial to cellular homeostasis, and cell death. In this report, we review key molecular causes of mitochondrial dysfunction and discuss how it influences insulin resistance, Pearson Syndrome and Kearns-Sayre syndrome, the latter of which occur due to pathogenic variants in mitochondrial DNA that lead to direct cellular pathology. We discuss the molecular and cellular pathophysiological mechanisms, disease interplays, and clinical considerations related to these diseases influenced by mitochondrial dysfunction.

Indexed as

insulin resistanceKearns-Sayre syndromemitochondrial dysfunctionPearson syndrome

Identifiers

PMID40959587
PMCPMC12435500

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.