ArticleInternational journal of general medicine2025
Platelet/Neutrophil Count Ratio (PNR) and Fibrinogen/Lymphocyte Count Ratio (FLR) Can Be Used as Predictive Indicators of Bone Metastasis in Non-Smoking Patients with Lung Cancer, but Not in Smoking Patients.
Article in International journal of general medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: The purpose of this study is to evaluate the relationship between some comprehensive indices (platelet-to-neutrophil ratio (PNR), fibrinogen-to-lymphocyte ratio (FLR), albumin-to-monocyte ratio (AMR)) and bone metastasis of lung cancer. Methods: A total of 1535 patients with lung cancer treated in Meizhou People's Hospital from November 2017 to May 2025 were retrospectively analyzed. Clinical characteristics (age, body mass index (BMI), bone metastasis, and PNR, FLR, and AMR levels) were collected. The optimal cutoff values of PNR, FLR, and AMR were calculated through the receiver operating characteristic (ROC) curve. The relationships between PNR, FLR, AMR and bone metastasis were analyzed. Results: There were 665 (665/1535, 43.3%) patients had bone metastasis and 870 (870/1535, 56.7%) without. The levels of PNR (54.11 (38.11, 79.59) vs 50.06 (33.55, 72.10), Conclusion: In conclusion, lung cancer mainly occurs in elderly men, among whom approximately 43% of patients have bone metastases. PNR and FLR have good predictive value in bone metastasis of non-smoking lung cancer patients.
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