ArticleFrontiers in public health2025
Study protocol: associations between hormonal profile and physical and cognitive functions in middle-aged men-a one-year cohort follow-up study.
Article in Frontiers in public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Middle age (45-64 years) is a critical yet under-researched phase of aging, during which the first signs of physical, cognitive, and hormonal decline often emerge. In men, testosterone (T) levels begin to decrease starting in the fourth decade of life. However, the relationship between T levels and functional abilities in midlife men remains poorly understood. A better understanding of how physical, cognitive, and hormonal domains interact during this transitional phase is essential for developing targeted interventions to promote healthy aging. Using advanced assessment tools, we propose a study aimed to clarify this association in middle-aged men. Methods: This is a one-year follow-up cohort study. Two hundred healthy middle-aged men will undergo comprehensive assessments, including blood tests, body composition analysis, balance and strength testing, and computerized cognitive evaluation. Half of the sample will perform a subset of the balance and strength tests with a smartphone on their back to obtain accelerometry based measures that have been shown to detect subtle functional changes in midlife. T levels will be measured again after 6 months, and a full assessment will be reperformed after 1 year. Expected results: We anticipate that men with higher T levels will have better physical and cognitive function, with these associations persisting over a one-year period. Conclusion: This study addresses a critical research gap by clarifying the relationships between hormonal, physical, and cognitive function during midlife. If significant associations are identified, T level assessments could be integrated into routine preclinical screenings alongside physical and cognitive evaluations.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.