Evidence map›Paper›PMID 40959694›Full record

ArticleFrontiers in nutrition2025

Assessing the association between the non-HDL to HDL cholesterol ratio and NAFLD in Chinese adults: concentrate on gout populations.

Cunwei Sun, Ke Si, Youzhuang Zhu, Chengqian Li, Yang Yu, Changxin Jia, Qing Wang

Abstract read
In one paragraph

Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Cunwei Sun *Department of Endocrinology and Metabolism, Affiliated Hospital of Qingdao University, Qingdao, China.
Ke Si *Department of Endocrinology and Metabolism, Affiliated Hospital of Qingdao University, Qingdao, China.
Youzhuang ZhuDepartment of Anesthesiology, Affiliated Hospital of Qingdao University, Qingdao, China.
Chengqian LiDepartment of Endocrinology and Metabolism, Affiliated Hospital of Qingdao University, Qingdao, China.
Yang YuDepartment of Laboratory Medicine, Affiliated Hospital of Qingdao University, Qingdao, China.
Changxin JiaDepartment of Anesthesiology, Affiliated Hospital of Qingdao University, Qingdao, China.
Qing WangDepartment of Endocrinology and Metabolism, Affiliated Hospital of Qingdao University, Qingdao, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The coexistence and synergistic relationship between Nonalcoholic fatty liver disease (NAFLD) and gout necessitate an investigation into the risk factors for NAFLD among individuals with gout. The non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) serves as a comprehensive lipid index. This study aimed to investigate the association between NHHR and the risk of NAFLD in patients with gout. Methods: A cross-sectional study was conducted involving 1,038 hospitalized patients with gout to examine the relationship between NHHR and NAFLD. NHHR was included in the logistic regression analysis as both a continuous and a categorical variable. Restricted cubic splines (RCS) were utilized to assess the dose-response relationship. Additionally, subgroup analyses were performed to identify potential interactions among variables. The predictive capability of NHHR was evaluated using the receiver operating characteristic (ROC) curve based on the basic model. Results: The analysis of quartile groups stratified by NHHR levels revealed an increased prevalence of NAFLD corresponding to higher NHHR levels. Multifactorial logistic regression analysis established a significant association between NHHR and NAFLD, yielding an odds ratio (OR) of 1.242 [95% confidence interval (CI): 1.089-1.416, Conclusion: This study identified a positive correlation between NHHR and the incidence of NAFLD in individuals with gout, suggesting that NHHR may serve as a reliable indicator of NAFLD within the gout patient.

Indexed as

cross-sectional studygoutHDLlipid indicatorNAFLDNHHRnon-HDL

Identifiers

PMID40959694
PMCPMC12433996

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.