Evidence map›Paper›PMID 40959971›Full record

ArticleCancer medicine2025

Focal Adhesion Kinase Intersects With the BRD4-MYC Axis and YAP1 to Drive Tumor Cell Growth, Phenotypic Plasticity, Stemness, and Metastatic Potential in Colorectal Cancer.

Rongbo Han, Junfeng Shi, Kai Cheng, Zian Wang, Yecang Chen, Orion Spellecy, Abu Saleh Mosa Faisal, Isha Aryal, Jinfei Chen, Rolf Craven and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Rongbo HanDepartment of Pharmacology and Nutritional Sciences, College of Medicine, University of Kentucky, Lexington, Kentucky, USA.
Junfeng ShiDepartment of Oncology, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu Province, China.
Kai ChengDepartment of Pathology, Nanjing Jinling Hospital, Nanjing University School of Medicine, Nanjing, Jiangsu Province, China.
Zian WangCollege of Food Science and Technology, Shanghai Ocean University, Shanghai, China.
Yecang ChenDepartment of Pharmacology and Nutritional Sciences, College of Medicine, University of Kentucky, Lexington, Kentucky, USA.
Orion SpellecyDepartment of Pharmacology and Nutritional Sciences, College of Medicine, University of Kentucky, Lexington, Kentucky, USA.
Abu Saleh Mosa FaisalMarkey Cancer Center and Department of Toxicology and Cancer Biology, College of Medicine, University of Kentucky, Lexington, Kentucky, USA.
Isha AryalDepartment of Pharmacology and Nutritional Sciences, College of Medicine, University of Kentucky, Lexington, Kentucky, USA.
Jinfei ChenDepartment of Oncology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.ORCID https://orcid.org/0000-0001-5874-3462
Rolf CravenDepartment of Pharmacology and Nutritional Sciences, College of Medicine, University of Kentucky, Lexington, Kentucky, USA.
Olivier ThibaultDepartment of Pharmacology and Nutritional Sciences, College of Medicine, University of Kentucky, Lexington, Kentucky, USA.
Lauren BaldwinMarkey Cancer Center and Department of Toxicology and Cancer Biology, College of Medicine, University of Kentucky, Lexington, Kentucky, USA.
Lawrence D BrewerDepartment of Pharmacology and Nutritional Sciences, College of Medicine, University of Kentucky, Lexington, Kentucky, USA.
Sonia ErfaniDepartment of Pharmacology and Nutritional Sciences, College of Medicine, University of Kentucky, Lexington, Kentucky, USA.
Chi WangMarkey Cancer Center and Department of Toxicology and Cancer Biology, College of Medicine, University of Kentucky, Lexington, Kentucky, USA.
Zhenheng GuoDepartment of Pharmacology and Nutritional Sciences, College of Medicine, University of Kentucky, Lexington, Kentucky, USA.
Eric ChenDivision of Medical Oncology and Hematology, Princess Margaret Cancer Center, University of Toronto, Toronto, Ontario, Canada.
Burton YangDepartment of Laboratory Medicine and Pathobiology, Sunnybrook Research Institute, University of Toronto, Toronto, Ontario, Canada.
Frederick UelandMarkey Cancer Center and Department of Toxicology and Cancer Biology, College of Medicine, University of Kentucky, Lexington, Kentucky, USA.ORCID https://orcid.org/0000-0003-1213-7509
Ruihua GuoCollege of Food Science and Technology, Shanghai Ocean University, Shanghai, China.
Xiuwei YangDepartment of Pharmacology and Nutritional Sciences, College of Medicine, University of Kentucky, Lexington, Kentucky, USA.ORCID https://orcid.org/0000-0002-5591-6951

Funding

American Cancer Society #IRG 85-001-25
6 · The paper itself

Abstract

objectiveColorectal cancer (CRC) remains one of the leading causes of cancer-related death worldwide due to the lack of effective therapies. Here we explored the clinical basis and therapeutic promise of the integrin-focal adhesion kinase (FAK)-dependent pathway for CRC. METHODS AND

resultsOur bioinformatic and histological analyses showed that FAK was markedly upregulated at both mRNA and protein and signaling levels in the two CRC patient cohorts. Particularly, the portion of carcinomas carrying active FAK (Y

conclusionOverall, our study highlights the potent pro-malignant role of the integrin-FAK axis in CRC, fueling its targeting as a single agent or synthetic lethal-based therapy.

Indexed as

Adaptor Proteins, Signal TransducingCell Cycle ProteinsColorectal NeoplasmsFocal Adhesion Kinase 1Focal Adhesion Protein-Tyrosine KinasesNeoplastic Stem CellsProto-Oncogene Proteins c-mycTranscription FactorsBromodomain Containing ProteinsCell Line, TumorCell MovementCell ProliferationGene Expression Regulation, NeoplasticHumansNeoplasm MetastasisPhenotypeAdaptor Proteins, Signal TransducingBRD4 protein, humanBromodomain Containing ProteinsCell Cycle ProteinsFocal Adhesion Kinase 1Focal Adhesion Protein-Tyrosine KinasesMYC protein, humanProto-Oncogene Proteins c-mycPTK2 protein, humanTranscription FactorsYAP1 protein, humanYAP-Signaling ProteinsBRD4colorectal cancerFAKmetastasisMYCtumor growth

Identifiers

PMID40959971
PMCPMC12441738

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.