Evidence map›Paper›PMID 40960435›Full record

ArticleJACC. Case reports2025

Pressure-Volume Loop Optimization of Cardiac Resynchronization Therapy in a Left Ventricular Assist Device Patient.

Sara S Inglis, Andrew N Rosenbaum, Martin Wong, Serena J Rahme, Sarah D Schettle, Thanat Chaikijurajai, Adrian J daSilva-deAbreu, Ammar M Killu, Alan M Sugrue, Atta Behfar

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. Case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sara S InglisDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, USA; Van Cleve Cardiac Regenerative Medicine Program, Mayo Clinic, Rochester, Minnesota, USA.
Andrew N RosenbaumDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, USA; Van Cleve Cardiac Regenerative Medicine Program, Mayo Clinic, Rochester, Minnesota, USA.
Martin WongDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Serena J RahmeDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, USA; Van Cleve Cardiac Regenerative Medicine Program, Mayo Clinic, Rochester, Minnesota, USA.
Sarah D SchettleDepartment of Cardiovascular Surgery, Mayo Clinic, Rochester, Minnesota, USA.
Thanat ChaikijurajaiDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Adrian J daSilva-deAbreuDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Ammar M KilluDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Alan M SugrueDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Atta BehfarDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, USA; Van Cleve Cardiac Regenerative Medicine Program, Mayo Clinic, Rochester, Minnesota, USA. Electronic address: Behfar.atta@mayo.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPatients with a left ventricular assist device (LVAD) often have a pre-existing cardiac resynchronization therapy (CRT) device, although guidelines highlight uncertainty surrounding postimplant programming. CASE SUMMARY: A 60-year-old man with a HeartMate 3 (Abbott) had left bundle branch-optimized CRT. Right/left heart catheterization with biventricular pressure-volume (PV) loops was performed for device optimization. WHY BEYOND THE GUIDELINES: Guidelines suggest that both leaving CRT on (remodeling benefit) or turning off (improve battery) may be appropriate for patients with LVAD. PV loops may serve as a powerful tool for guiding individualized device optimization. DISCUSSION: Optimal pacing was determined based on greatest benefit in biventricular contractility and volume reduction. The results highlight the complexity of biventricular interaction in CRT, particularly in an LVAD patient. TAKE-HOME MESSAGE: Biventricular PV loops provide unique insight to individualize optimization of native ventricular function in continuous flow device-based support.

Indexed as

cardiac resynchronization therapycardiomyopathychronic heart failure

Identifiers

PMID40960435
PMCPMC12793881

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.