Evidence map›Paper›PMID 40960700›Full record

ReviewMolecular biology reports2025

Exploring the frontier of non-coding RNAs: biogenesis, functional diversity, and disease associations of circRNAs and tinyRNAs.

Hilal-Nur Calisir, Sila Akcay, Enes Bal, Pelin Ozfiliz-Kilbas, Buse Ozden, Burcu Ayhan-Sahin

Abstract readReview
PubMed Publisher
In one paragraph

Review in Molecular biology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. The role of epigenetic alterations in canine mammary cancer.The Journal of reproduction and development · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hilal-Nur Calisir *Department of Molecular Biology and Genetics, Istanbul Kultur University, Bakırkoy Campus, Ataköy Building, E5 Highway, Bakırköy, Istanbul, 34158, Turkey.
Sila Akcay *Department of Molecular Biology and Genetics, Istanbul Kultur University, Bakırkoy Campus, Ataköy Building, E5 Highway, Bakırköy, Istanbul, 34158, Turkey.
Enes BalDepartment of Molecular Biology and Genetics, Istanbul Kultur University, Bakırkoy Campus, Ataköy Building, E5 Highway, Bakırköy, Istanbul, 34158, Turkey.
Pelin Ozfiliz-KilbasDepartment of Molecular Biology and Genetics, Istanbul Kultur University, Bakırkoy Campus, Ataköy Building, E5 Highway, Bakırköy, Istanbul, 34158, Turkey.
Buse OzdenDepartment of Molecular Biology and Genetics, Istanbul Kultur University, Bakırkoy Campus, Ataköy Building, E5 Highway, Bakırköy, Istanbul, 34158, Turkey.
Burcu Ayhan-SahinDepartment of Molecular Biology and Genetics, Istanbul Kultur University, Bakırkoy Campus, Ataköy Building, E5 Highway, Bakırköy, Istanbul, 34158, Turkey. burcu.sahin@iku.edu.tr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Non-coding RNAs (ncRNAs) represent a pivotal frontier in molecular biology, expanding our understanding of genetic regulation beyond the classical central dogma. Among these, circular RNAs (circRNAs) and tiny RNAs (tyRNAs) have emerged as critical regulators with diverse roles in gene expression, cellular homeostasis, and disease pathogenesis. CircRNAs, characterized by their covalently closed structures, exhibit remarkable stability and functional versatility, including acting as microRNA sponges, transcriptional regulators, and protein scaffolds. Tiny RNAs, a newly recognized class of ncRNAs, are implicated in post-transcriptional regulation through interactions with Argonaute proteins, influencing pathways from viral defense to neurodegenerative diseases. This review synthesizes recent advancements in the biogenesis, molecular mechanisms, and clinical significance of circRNAs and tyRNAs, highlighting their potential as biomarkers and therapeutic targets in cancer, metabolic disorders, and neurological conditions. By exploring their unique regulatory landscapes, this work aims to inspire further research into the ncRNA universe and its implications for human health.

Indexed as

RNA, CircularRNA, Small UntranslatedRNA, UntranslatedAnimalsGene Expression RegulationHumansMicroRNAsNeoplasmsNeurodegenerative DiseasesMicroRNAsRNA, CircularRNA, Small UntranslatedRNA, UntranslatedBiomarkers and therapeutic targetsCircular RNA (circRNA)Gene expression regulationNoncoding RNA (ncRNA)Tiny RNA (tyRNA)

Identifiers

PMID40960700

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.