ArticleEpigenetics2025
ACMSD methylation in peripheral blood is associated with dynamic functional connectivity pattern in adolescent MDD patients.
Article in Epigenetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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12 authors.
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Abstract
This study aimed to explore the association between ACMSD methylation level in peripheral blood and brain dynamic functional connectivity (dFC) patterns in adolescents with MDD. Sixty-seven drug-naive, first-episode adolescents with MDD (mean age 14.55 ± 1.38 years, 24 males [35.8%]) and twenty-three healthy controls (HCs, mean age 14.34 ± 1.47 years, 10 males [43.5%]) completed resting-state structural and functional magnetic resonance imaging. DNA samples were collected from peripheral venous blood. Joint and Individual Variation Explained (JIVE) method was used to explore the joint and independent components of four domains of environmental factors (life adverse events, LAE; family environment, FE; family functioning, FF; childhood chronic stress, CCS). Dynamic independent component analysis was used to compute dynamic functional connectivity between brain regions. Associations between ACMSD methylation, environment and brain dFC patterns were assessed. JIVE calculated one joint (JIVE-joint) and seven individual components (JIVE-LAE-1, JIVE-FE-1, JIVE-FE-2, JIVE-FF-1, JIVE-FF-2, JIVE-CCS-1, and JIVE-CCS-2). ACMSD methylation was negatively correlated with JIVE-joint (
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