Evidence map›Paper›PMID 40960855›Full record

ArticleCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2025

Elevated Resting Heart Rate Is an Independent Risk Factor for Mortality in Patients with Colorectal Cancer: A Retrospective Cohort Study.

Wonhee Cho, Ho Seung Kim, Dong Hoon Lee, Dong-Hyuk Park, Mi Kyung Lee, Seung Yoon Yang, Byung Soh Min, Kerry S Courneya, Jeffrey A Meyerhardt, Edward Giovannucci and 2 more

Abstract read
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In one paragraph

Article in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Wonhee ChoDepartment of Sport Industry Studies, Yonsei University, Seoul, South Korea.ORCID 0000-0003-3850-1495
Ho Seung KimDepartment of Surgery, College of Medicine, Yonsei University, Seoul, South Korea.ORCID 0000-0002-7378-0584
Dong Hoon LeeDepartment of Sport Industry Studies, Yonsei University, Seoul, South Korea.ORCID 0000-0003-1329-4637
Dong-Hyuk ParkDepartment of Sport Industry Studies, Yonsei University, Seoul, South Korea.ORCID 0000-0002-2545-3132
Mi Kyung LeeFrontier Research Institute of Convergence Sports Science, Yonsei University, Seoul, South Korea.ORCID 0000-0002-9690-4463
Seung Yoon YangDepartment of Surgery, College of Medicine, Yonsei University, Seoul, South Korea.ORCID 0000-0001-8129-7712
Byung Soh MinDepartment of Surgery, College of Medicine, Yonsei University, Seoul, South Korea.ORCID 0000-0003-0180-8565
Kerry S CourneyaFaculty of Kinesiology, Sport, and Recreation, University of Alberta, Edmonton, Canada.ORCID 0000-0002-9677-3918
Jeffrey A MeyerhardtDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.ORCID 0000-0002-1120-0898
Edward GiovannucciDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.ORCID 0000-0002-6123-0219
Nam-Kyu KimDepartment of Surgery, College of Medicine, Yonsei University, Seoul, South Korea.ORCID 0000-0003-0639-5632
Justin Y JeonDepartment of Sport Industry Studies, Yonsei University, Seoul, South Korea.ORCID 0000-0001-7978-4271

Funding

American Cancer Society (ACS) CRP-23-1014041Yonsei University (YONSEI University, Seoul, Korea) Yonsei University Signature Cluster
6 · The paper itself

Abstract

backgroundAlthough lifestyle factors are associated with resting heart rate (RHR), its association with mortality in patients with colorectal cancer has not been fully understood. Therefore, we sought to determine whether RHR is associated with all-cause and colorectal cancer-specific mortality in patients with stage I to III colorectal cancer.

methodsWe included a total of 3,631 patients from the Severance Hospital Colorectal Cancer Registry (Seoul, South Korea) who underwent surgery for stage I to III colorectal cancer. RHR data were collected on the day of surgery. We utilized multivariable Cox proportional hazards models to estimate HRs and 95% confidence intervals (CI) for the association between RHR and all-cause and colorectal cancer-specific mortality.

resultsDuring a median follow-up of 3.0 years, there were 292 all-cause and 177 colorectal cancer-specific deaths. Patients in the highest quintile of RHR [≥88 beats per minute (bpm)] versus patients in the lowest quintile of RHR (≤66 bpm) showed a 3.33-fold increased risk of all-cause mortality (95% CI, 1.85-5.99) and a 2.98-fold increased risk of colorectal cancer-specific mortality (95% CI, 1.72-5.16). For every 10-bpm increase in RHR, there was a 1.44-fold increase in all-cause mortality (95% CI, 1.32-1.58) and a 1.50-fold increase in colorectal cancer-specific mortality (95% CI, 1.33-1.69).

conclusionsElevated RHR on the day of surgery for colorectal cancer is associated with a higher risk of all-cause/colorectal cancer-specific mortality. IMPACT: Our data suggest that RHR may serve as a clinically relevant predictor of mortality in patients who undergo surgery for colorectal cancer.

Indexed as

Colorectal NeoplasmsHeart RateAgedFemaleHumansMaleMiddle AgedRepublic of KoreaRetrospective StudiesRisk Factors

Identifiers

PMID40960855

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.