Evidence mapPaperPMID 40960937Full record

ArticleAmerican journal of physiology. Cell physiology2025

Cannabis improves metabolic dysfunction and macrophage signatures in obese mice.

Brandon N VanderVeen, Thomas D Cardaci, Christian A Unger, Mitchell M NeSmith, Jeffrey C Freeman, Arianna V Bastian, Kasie Roark, Mansi Upadhyay, Andrew G Levy, Brooke M Bullard and 8 more

Abstract read
In one paragraph

Article in American journal of physiology. Cell physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Brandon N VanderVeenDepartment of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States.ORCID 0000-0002-4535-0544
Thomas D CardaciDepartment of Pathology, Microbiology, and Immunology, University of South Carolina School of Medicine, Columbia, South Carolina, United States.ORCID 0000-0002-4339-819X
Christian A UngerDepartment of Pathology, Microbiology, and Immunology, University of South Carolina School of Medicine, Columbia, South Carolina, United States.ORCID 0000-0001-9776-4688
Mitchell M NeSmithDepartment of Pathology, Microbiology, and Immunology, University of South Carolina School of Medicine, Columbia, South Carolina, United States.
Jeffrey C FreemanDepartment of Pathology, Microbiology, and Immunology, University of South Carolina School of Medicine, Columbia, South Carolina, United States.ORCID 0009-0008-3244-6863
Arianna V BastianDepartment of Pathology, Microbiology, and Immunology, University of South Carolina School of Medicine, Columbia, South Carolina, United States.
Kasie RoarkDepartment of Pathology, Microbiology, and Immunology, University of South Carolina School of Medicine, Columbia, South Carolina, United States.
Mansi UpadhyayDepartment of Pathology, Microbiology, and Immunology, University of South Carolina School of Medicine, Columbia, South Carolina, United States.
Andrew G LevyDepartment of Pathology, Microbiology, and Immunology, University of South Carolina School of Medicine, Columbia, South Carolina, United States.
Brooke M BullardDepartment of Pathology, Microbiology, and Immunology, University of South Carolina School of Medicine, Columbia, South Carolina, United States.ORCID 0000-0003-0923-9950
Sierra J McDonaldLineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, United States.
Kandy T VelázquezDepartment of Pathology, Microbiology, and Immunology, University of South Carolina School of Medicine, Columbia, South Carolina, United States.ORCID 0000-0003-2427-165X
Reilly T EnosDepartment of Pathology, Microbiology, and Immunology, University of South Carolina School of Medicine, Columbia, South Carolina, United States.
Jason L KubinakDepartment of Pathology, Microbiology, and Immunology, University of South Carolina School of Medicine, Columbia, South Carolina, United States.
Lorne J HofsethDepartment of Drug Discovery and Biomedical Sciences, College of Pharmacy, University of South Carolina, Columbia, South Carolina, United States.
James R HebertCancer Prevention and Control Program, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina, United States.ORCID 0000-0002-0677-2672
Daping FanDepartment of Cell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, South Carolina, United States.
E Angela MurphyDepartment of Pathology, Microbiology, and Immunology, University of South Carolina School of Medicine, Columbia, South Carolina, United States.ORCID 0000-0002-4803-5822

Funding

The Center for Clinical and Translational Research at the University of South Carolina (CLINTRUSC)P20GM155896 · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · 2025 to 2025
$2.9M
A Transdisciplinary Approach to Investigating Metabolic Dysregulation in Obese Parent and Child Dyads and Risk of Colorectal CancerU01CA272977 · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · 2025 to 2025
$1.1M
Impact of Obesity on Chemotherapy-Induced Cytotoxicity: Immune Cells and Skeletal MuscleR00CA276891 · WAKE FOREST UNIVERSITY HEALTH SCIENCES · 2025 to 2025
$249k
Microbiome-Mitochondrial Interactions Driving Cancer-Induced Cachexia in the Obese StateF99CA294251 · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · 2025 to 2025
$39k
NCCIH NIH HHS F31 AT012589NCI NIH HHS F31 CA278490NCI NIH HHS F99 CA294251NCI NIH HHS K99 CA276891NCI NIH HHS R00 CA276891NCI NIH HHS U01 CA272977NIGMS NIH HHS P20 GM155896
6 · The paper itself

Abstract

Obesity rates continue to rise, highlighting the need for new treatments that are effective, safe, and widely accessible. Aligned with the easing of restrictions on cannabis use, interest in its therapeutic potential is evolving. As such, we examined the effects of the cannabis plant with high cannabidiol (CBD) content or high Δ

Indexed as

CannabidiolCannabisDronabinolMacrophagesObesityAnimalsDiet, High-FatFemaleInsulin ResistanceLiverMiceMice, Inbred C57BLMice, ObeseCannabidiolDronabinolcannabidiolimmune cellsmetabolismobesityΔ9-tetrahydrocannabinol

Identifiers

PMID40960937
PMCPMC12914386

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.