ArticlePloS one2025
Trends and disparities in Non-Hodgkin Lymphoma related mortality in the United States, 1999-2020.
Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It carries an expression of concern. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
Corrections and comments
- Expression of concern
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNon-Hodgkin Lymphoma (NHL) is the most prevalent hematological malignancy worldwide, making its mortality trends a critical public health concern. This study examines temporal trends in NHL-related mortality in the United States from 1999 to 2020, with a focus on sex-based, racial, and regional disparities.
methodsData were obtained from the Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiologic Research (CDC WONDER) database. Crude and age-adjusted mortality rates (AAMR) were analyzed and annual percentage changes (APCs) were calculated using Joinpoint regression to identify temporal trends.
resultsAmong 560,469 NHL-related deaths, AAMR declined from 12.86 (1999) to 8.26 per 100,000 (2020), with an increasing trend from 2018 to 2020 (APC: 0.89 [95% CI, -0.55 to 1.64]). Males consistently exhibited higher mortality rates compared to females (12.62 vs. 7.58), and NH White Americans exhibited the highest mortality among racial groups (10.34). Regional disparities were evident, with the Midwestern region recording the highest AAMR (10.64), and Minnesota, Nebraska, Iowa, Ohio and Vermont exhibiting the highest state-specific rates. Nonmetropolitan areas exhibited higher mortality rates than metropolitan areas (10.28 vs 9.62).
conclusionWhile NHL-related mortality in the U.S. has declined overall, recent upward trends from 2018 to 2020, particularly among certain demographic and geographic subgroups, raise concerns. These findings highlight the need for further investigation into underlying factors and targeted interventions to address disparities and improve NHL outcomes.
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