ArticleCell reports. Medicine2025
ATM deficiency drives phenotypic diversity and Purkinje cell degeneration in a macaque model of ataxia-telangiectasia.
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Article in Cell reports. Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3citing papers in PubMed
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Who cites it
3 citing papers in PubMed.
- Recent Advances in Therapy for the Neurodegenerative Disorder Ataxia-Telangiectasia.International journal of molecular sciences · 2026Review
- ATM-kinase deficiency triggers early multi-compartment remodeling of the cerebellar microenvironment.Acta neuropathologica communications · 2026Article
- Animal models of critical illness in the Asia-Pacific region: current practices, shared challenges, and future directions.Intensive care medicine experimental · 2026Review
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Authors and funding
21 authors.
Kaiyu XuState Key Laboratory of Genetic Evolution and Animal Models, Key Laboratory of Animal Models and Human Disease Mechanisms of Yunnan Province, Yunnan Engineering Center on Brain Disease Models, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, National Research Facility for Phenotypic and Genetic Analysis of Model Animals (Primate Facility), National Resource Center for Non-Human Primates, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China.
Ying ZhangState Key Laboratory of Genetic Evolution and Animal Models, Key Laboratory of Animal Models and Human Disease Mechanisms of Yunnan Province, Yunnan Engineering Center on Brain Disease Models, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, National Research Facility for Phenotypic and Genetic Analysis of Model Animals (Primate Facility), National Resource Center for Non-Human Primates, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China.
Yongxuan ChenState Key Laboratory of Genetic Evolution and Animal Models, Key Laboratory of Animal Models and Human Disease Mechanisms of Yunnan Province, Yunnan Engineering Center on Brain Disease Models, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, National Research Facility for Phenotypic and Genetic Analysis of Model Animals (Primate Facility), National Resource Center for Non-Human Primates, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China; Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan, China.
Xiaojia ZhuState Key Laboratory of Genetic Evolution and Animal Models, Key Laboratory of Animal Models and Human Disease Mechanisms of Yunnan Province, Yunnan Engineering Center on Brain Disease Models, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, National Research Facility for Phenotypic and Genetic Analysis of Model Animals (Primate Facility), National Resource Center for Non-Human Primates, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China; Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan, China.
Yu LiState Key Laboratory of Genetic Evolution and Animal Models, Key Laboratory of Animal Models and Human Disease Mechanisms of Yunnan Province, Yunnan Engineering Center on Brain Disease Models, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, National Research Facility for Phenotypic and Genetic Analysis of Model Animals (Primate Facility), National Resource Center for Non-Human Primates, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China.
Longbao LvState Key Laboratory of Genetic Evolution and Animal Models, Key Laboratory of Animal Models and Human Disease Mechanisms of Yunnan Province, Yunnan Engineering Center on Brain Disease Models, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, National Research Facility for Phenotypic and Genetic Analysis of Model Animals (Primate Facility), National Resource Center for Non-Human Primates, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China; Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan, China.
Xiechao HeState Key Laboratory of Genetic Evolution and Animal Models, Key Laboratory of Animal Models and Human Disease Mechanisms of Yunnan Province, Yunnan Engineering Center on Brain Disease Models, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, National Research Facility for Phenotypic and Genetic Analysis of Model Animals (Primate Facility), National Resource Center for Non-Human Primates, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China.
Zhengfei HuState Key Laboratory of Genetic Evolution and Animal Models, Key Laboratory of Animal Models and Human Disease Mechanisms of Yunnan Province, Yunnan Engineering Center on Brain Disease Models, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, National Research Facility for Phenotypic and Genetic Analysis of Model Animals (Primate Facility), National Resource Center for Non-Human Primates, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China.
Yifan LiState Key Laboratory of Genetic Evolution and Animal Models, Key Laboratory of Animal Models and Human Disease Mechanisms of Yunnan Province, Yunnan Engineering Center on Brain Disease Models, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, National Research Facility for Phenotypic and Genetic Analysis of Model Animals (Primate Facility), National Resource Center for Non-Human Primates, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China.
Maosen YeState Key Laboratory of Genetic Evolution and Animal Models, Key Laboratory of Animal Models and Human Disease Mechanisms of Yunnan Province, Yunnan Engineering Center on Brain Disease Models, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, National Research Facility for Phenotypic and Genetic Analysis of Model Animals (Primate Facility), National Resource Center for Non-Human Primates, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China.
Dewei JiangState Key Laboratory of Genetic Evolution and Animal Models, Key Laboratory of Animal Models and Human Disease Mechanisms of Yunnan Province, Yunnan Engineering Center on Brain Disease Models, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, National Research Facility for Phenotypic and Genetic Analysis of Model Animals (Primate Facility), National Resource Center for Non-Human Primates, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China.
Zhanlong HeInstitute of Medical Biology, Chinese Academy of Medical Sciences, Peking Union Medical College, Kunming, Yunnan, China.
Weihua JinInstitute of Medical Biology, Chinese Academy of Medical Sciences, Peking Union Medical College, Kunming, Yunnan, China.
Yanyan LiInstitute of Medical Biology, Chinese Academy of Medical Sciences, Peking Union Medical College, Kunming, Yunnan, China.
Xiaomei YuState Key Laboratory of Genetic Evolution and Animal Models, Key Laboratory of Animal Models and Human Disease Mechanisms of Yunnan Province, Yunnan Engineering Center on Brain Disease Models, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, National Research Facility for Phenotypic and Genetic Analysis of Model Animals (Primate Facility), National Resource Center for Non-Human Primates, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China.
Deng-Feng ZhangState Key Laboratory of Genetic Evolution and Animal Models, Key Laboratory of Animal Models and Human Disease Mechanisms of Yunnan Province, Yunnan Engineering Center on Brain Disease Models, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, National Research Facility for Phenotypic and Genetic Analysis of Model Animals (Primate Facility), National Resource Center for Non-Human Primates, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China.
Karl HerrupDepartment of Neurobiology, The University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Ping ZhengState Key Laboratory of Genetic Evolution and Animal Models, Key Laboratory of Animal Models and Human Disease Mechanisms of Yunnan Province, Yunnan Engineering Center on Brain Disease Models, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, National Research Facility for Phenotypic and Genetic Analysis of Model Animals (Primate Facility), National Resource Center for Non-Human Primates, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China; Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan, China.
Yong-Gang YaoState Key Laboratory of Genetic Evolution and Animal Models, Key Laboratory of Animal Models and Human Disease Mechanisms of Yunnan Province, Yunnan Engineering Center on Brain Disease Models, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, National Research Facility for Phenotypic and Genetic Analysis of Model Animals (Primate Facility), National Resource Center for Non-Human Primates, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China; Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan, China. Electronic address: yaoyg@mail.kiz.ac.cn.
Dong-Dong WuState Key Laboratory of Genetic Evolution and Animal Models, Key Laboratory of Animal Models and Human Disease Mechanisms of Yunnan Province, Yunnan Engineering Center on Brain Disease Models, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, National Research Facility for Phenotypic and Genetic Analysis of Model Animals (Primate Facility), National Resource Center for Non-Human Primates, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China; Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan, China. Electronic address: wudongdong@mail.kiz.ac.cn.
Jiali LiState Key Laboratory of Genetic Evolution and Animal Models, Key Laboratory of Animal Models and Human Disease Mechanisms of Yunnan Province, Yunnan Engineering Center on Brain Disease Models, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, National Research Facility for Phenotypic and Genetic Analysis of Model Animals (Primate Facility), National Resource Center for Non-Human Primates, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China; Department of Neurology, Hackensack Meridian School of Medicine, Nutley, NJ, USA. Electronic address: jiali.li@hmhn.org.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ataxia-telangiectasia (A-T) is a hereditary neurodegenerative disorder caused by mutations in the ATM (ataxia-telangiectasia mutated) gene. Although existing rodent models reproduce some of the multi-systemic features of A-T, they notably fail to recapitulate the severe neurological manifestations, particularly the profound cerebellar atrophy and associated ataxia. To address this limitation, we have generated ATM-deficient rhesus macaques using CRISPR-Cas9. These macaques exhibit hallmark features of A-T, including growth retardation, lymphopenia, elevated a-fetoprotein levels, oculocutaneous telangiectasias, heightened sensitivity to ionizing radiation, and most critically, cerebellar atrophy, Purkinje cell loss, and early-stage cerebellar neurodegeneration leading to significant motor impairments. Single-nucleus transcriptomic profiling of the cerebellum revealed pronounced gene expression changes associated with ATM deficiency, particularly in molecular layer interneurons (MLIs), which are implicated in Purkinje cell loss. This non-human primate model provides deeper insights into the pathogenesis of A-T and represents a promising and valuable platform for developing therapeutic strategies.
Indexed as
Ataxia TelangiectasiaAtaxia Telangiectasia Mutated ProteinsPurkinje CellsAnimalsCerebellumDisease Models, AnimalMacaca mulattaMalePhenotypeAtaxia Telangiectasia Mutated Proteinsataxia-telangiectasiaATM deficiencycerebellar atrophyCRISPR-Cas9magnetic resonance imaging, MRINonhuman primate disease modelPurkinje cell degenerationsnRNA-seq
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LicenceCC BY-NC-ND
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