Evidence map›Paper›PMID 40962808›Full record

ArticleSignal transduction and targeted therapy2025

Pantothenate kinase 4 controls lipid synthesis for T-cell proliferation by modulating coenzyme A and glutaminolysis.

Jeong-Ryul Hwang, Chi Thi Ngoc Nguyen, Gwanghoon Ko, Jung-Ah Kang, Yeongseon Byeon, Seowoo Park, Ryunha Chang, Dawoon Jung, Mi Yeon Jeon, Young Hoon Sung and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Signal transduction and targeted therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Jeong-Ryul Hwang *College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University, Seoul, Republic of Korea.
Chi Thi Ngoc Nguyen *College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University, Seoul, Republic of Korea.
Gwanghoon Ko *College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University, Seoul, Republic of Korea.
Jung-Ah KangBio-Nanotechnology Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea.
Yeongseon ByeonSchool of Life Sciences, Gwangju Institute of Science and Technology (GIST), Gwangju, Republic of Korea.
Seowoo ParkCollege of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University, Seoul, Republic of Korea.
Ryunha ChangCollege of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University, Seoul, Republic of Korea.
Dawoon JungCollege of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University, Seoul, Republic of Korea.
Mi Yeon JeonDepartment of Cell and Genetic Engineering, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
Young Hoon SungDepartment of Cell and Genetic Engineering, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
Cho-Rong LeeCollege of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University, Seoul, Republic of Korea.
Ki-Hoan NamLaboratory Animal Resource and Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju, Republic of Korea.
Je Kyung SeongKorea Mouse Phenotyping Center, Seoul National University, Seoul, Republic of Korea.ORCID 0000-0003-1177-6958
Sankar GhoshDepartment of Microbiology and Immunology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.ORCID 0000-0002-3227-0588
Yun Pyo KangCollege of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University, Seoul, Republic of Korea. yunpyo.kang@snu.ac.kr.ORCID 0000-0002-1149-0880
Sung-Gyoo ParkCollege of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University, Seoul, Republic of Korea. riceo2@snu.ac.kr.ORCID 0000-0003-3702-5765

Funding

Ministry of Food and Drug Safety (MFDS) RS-2024-00331849National Research Foundation of Korea (NRF) NRF-2021R1A2C3011211National Research Foundation of Korea (NRF) NRF-2022M3A9I2017587National Research Foundation of Korea (NRF) NRF-2022R1C1C1003619Seoul National University 370-2024114Seoul National University Ascending SNU Future Leader Fellowship
6 · The paper itself

Abstract

During T-cell-mediated inflammatory responses, T cells are activated upon recognizing specific antigens presented by antigen-presenting cells. This recognition initiates signaling through the TCR and CD28, leading to their activation and subsequent clonal expansion. Within the signaling cascades triggered by TCR and CD28 engagement, the CD28-PI3K pathway serves as a central regulator of metabolic reprogramming in T cells, supporting the biosynthetic needs essential for their effective proliferation. In this study, we found that the regulation of PANK4 plays a role in TCR/CD28-mediated CD4

Indexed as

CD4-Positive T-LymphocytesCoenzyme AColitisGlutamineLipidsPhosphotransferases (Alcohol Group Acceptor)AnimalsCD28 AntigensCell ProliferationHumansLymphocyte ActivationMiceReceptors, Antigen, T-CellSignal TransductionCD28 AntigensCoenzyme AGlutamineLipidspantothenate kinasePhosphotransferases (Alcohol Group Acceptor)Receptors, Antigen, T-Cell

Identifiers

PMID40962808
PMCPMC12443970

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.