Evidence map›Paper›PMID 40962834›Full record

ArticleNature communications2025

GALNTL5 binds GalNAc and is required for migration through the uterotubal junction and sperm-zona pellucida binding.

Taichi Noda, Reika Uriu, Daisuke Mashiko, Hina Shinohara, Yongcun Qu, Ayumu Taira, Ryan M Matzuk, Duri Tahala, Motochika Nakano, Kimi Araki and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Taichi Noda *Institute of Resource Development and Analysis, Kumamoto University, 2-2-1 Honjo, Chuo-ku, Kumamoto, Japan. noda-t@kumamoto-u.ac.jp.ORCID http://orcid.org/0000-0003-0260-7861
Reika Uriu *Institute of Resource Development and Analysis, Kumamoto University, 2-2-1 Honjo, Chuo-ku, Kumamoto, Japan.ORCID http://orcid.org/0009-0000-9903-2595
Daisuke MashikoResearch Institute for Microbial Diseases, The University of Osaka, 3-1 Yamadaoka, Suita, Osaka, Japan.ORCID http://orcid.org/0000-0003-3927-3076
Hina ShinoharaInstitute of Resource Development and Analysis, Kumamoto University, 2-2-1 Honjo, Chuo-ku, Kumamoto, Japan.
Yongcun QuInstitute of Artificial Intelligence in Sports (IAIS), Capital University of Physical Education and Sports, Beijing, P. R. China.
Ayumu TairaInstitute of Resource Development and Analysis, Kumamoto University, 2-2-1 Honjo, Chuo-ku, Kumamoto, Japan.
Ryan M MatzukCenter for Drug Discovery and Department of Pathology & Immunology, Baylor College of Medicine, One Baylor Plaza, Houston, TX, USA.ORCID http://orcid.org/0000-0001-6426-752X
Duri TahalaInstitute of Resource Development and Analysis, Kumamoto University, 2-2-1 Honjo, Chuo-ku, Kumamoto, Japan.ORCID http://orcid.org/0009-0008-0211-8631
Motochika NakanoInstitute of Resource Development and Analysis, Kumamoto University, 2-2-1 Honjo, Chuo-ku, Kumamoto, Japan.
Kimi ArakiInstitute of Resource Development and Analysis, Kumamoto University, 2-2-1 Honjo, Chuo-ku, Kumamoto, Japan.ORCID http://orcid.org/0000-0002-1396-1527
Zhifeng YuCenter for Drug Discovery and Department of Pathology & Immunology, Baylor College of Medicine, One Baylor Plaza, Houston, TX, USA.ORCID http://orcid.org/0000-0002-3130-6438
Ying ZhangThe Key Laboratory of Cell Proliferation and Regulation Biology, Ministry of Education, College of Life Sciences, Beijing Normal University, Beijing, China.ORCID http://orcid.org/0000-0003-4082-5026
Martin M MatzukCenter for Drug Discovery and Department of Pathology & Immunology, Baylor College of Medicine, One Baylor Plaza, Houston, TX, USA. mmatzuk@bcm.edu.ORCID http://orcid.org/0000-0002-1445-8632
Masahito IkawaResearch Institute for Microbial Diseases, The University of Osaka, 3-1 Yamadaoka, Suita, Osaka, Japan. ikawa@biken.osaka-u.ac.jp.ORCID http://orcid.org/0000-0001-9859-6217

Funding

Functional analysis of novel testis-expressed secreted and transmembrane proteinsR01HD088412 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI MARTIN M. MATZUK · 2016 to 2026
$4.5M
Japan Agency for Medical Research and Development (AMED) JP23jf0126001MEXT | Japan Society for the Promotion of Science (JSPS) JP20H03172MEXT | Japan Society for the Promotion of Science (JSPS) JP21H05033MEXT | Japan Society for the Promotion of Science (JSPS) JP22H04922 (AdAMS)MEXT | Japan Society for the Promotion of Science (JSPS) JP23K20043MEXT | Japan Society for the Promotion of Science (JSPS) JP25K02196MEXT | Japan Society for the Promotion of Science (JSPS) JP25KJ1979MEXT | JST | Core Research for Evolutional Science and Technology (CREST) JPMJCR21N1MEXT | JST | Precursory Research for Embryonic Science and Technology (PRESTO) JPMJPR2148NICHD NIH HHS R01 HD088412U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) R01HD088412
6 · The paper itself

Abstract

More than 20 genes expressed in the male reproductive tract have been identified as essential factors for sperm migration to and through the utero-tubal junction (UTJ), and they are divided into ADAM3-dependent and ADAM3-independent pathways. In parallel, sperm having UTJ migration defects also show impaired binding to the zona pellucida (ZP). Herein, we demonstrate that knockout of Galntl5, encoding a sperm surface protein, causes impaired sperm binding with the UTJ and ZP, and null males have severe infertility. GALNTL5 appreciably disappears in sperm lacking Adam3 or Lypd4, required for ADAM3-dependent and ADAM3-independent pathways, and GALNTL5 binds to N-acetylgalactosamine (GalNAc) distributed on the UTJ and ZP. Blockage of GalNAc decreases the number of sperm binding to the UTJ and ZP. Thus, we unveil that GALNTL5 is a responsible factor for UTJ migration and sperm-ZP binding, and that sperm bind to the UTJ and ZP through interaction of GALNTL5 and GalNAc.

Indexed as

AcetylgalactosamineFallopian TubesLectinsN-AcetylgalactosaminyltransferasesSpermatozoaSperm-Ovum InteractionsUterusZona PellucidaADAM ProteinsAnimalsFemaleHumansInfertility, MaleMaleMembrane GlycoproteinsMiceAcetylgalactosamineAdam3 protein, mouseADAM ProteinsLectinsMembrane GlycoproteinsN-AcetylgalactosaminyltransferasesPolypeptide N-acetylgalactosaminyltransferase

Identifiers

PMID40962834
PMCPMC12443989

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.