ArticleExperimental brain research2025
Sex-dependent role of hippocampal BDNF and GSK-3β in mediating PTSD-like behaviors in both sexes of adolescent rats exposed to fear conditioning, extinction, and reinstatement.
Article in Experimental brain research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- A novel finding on sex-dependent diverse behavioral responses to the anticipation of a threat in a rat model of fear conditioning with the involvement of brain-derived neurotrophic factor (BDNF) in the prefrontal cortex.Learning & behavior · 2026Article
- Investigating brain-derived neurotrophic factor (BDNF) changes in three main rodent models of autism spectrum disorder (ASD): a systematic review.Neurotoxicity research · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Evidence has shown the role of brain-derived neurotrophic factor (BDNF) and glycogen synthase kinase-3 beta (GSK-3β) in the pathophysiology of posttraumatic stress disorder (PTSD). The present research explored the role of BDNF and GSK-3β activity in behavioral alterations in adolescent rats exposed to fear conditioning, extinction, and reinstatement. Three footshocks (0.8 mA for 3 s paired with sound 75 dB, 3 s) were delivered to rats. Extinction was done 1 min, or 1 h, or 1 day, or 5 days after conditioning (sound broadcasted for 20 times with no footshocks, 75 dB, 3 s). Reinstatement (one footshock, 0.8 mA, 3 s, with no sound) was done 1 h after extinction. The results showed extinction + reinstatement only in females decreased PTSD-like behaviors (darting was observed only in females). Fear conditioning decreased locomotion and rearing in both sexes, while extinction + reinstatement increased locomotion more effectively in females and rearing only in females. Fear conditioning decreased BDNF and increased GSK-3β more effectively in females, while extinction + reinstatement increased BDNF and decreased GSK-3β more effectively in females. In conclusion, we showed that BDNF and GSK-3β activity in the hippocampus may be involved in behavioral changes induced by fear conditioning and extinction + reinstatement sessions in females. However, it seems that behavioral changes in males may not be directly related to the function of BDNF and GSK-3β, although due to the absence of protein assessment, this conclusion is made with great caution. Additionally, reinstatement may induce a more powerful effect in males, counteracting the potential therapeutic effects of extinction session.
Indexed as
Identifiers
40962939What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.