Evidence map›Paper›PMID 40963014›Full record

ArticleNature2025

Co-option of an ancestral cloacal regulatory landscape during digit evolution.

Aurélie Hintermann, Christopher C Bolt, M Brent Hawkins, Guillaume Valentin, Lucille Lopez-Delisle, Madeline M Ryan, Sandra Gitto, Paula Barrera Gómez, Bénédicte Mascrez, Thomas A Mansour and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Aurélie Hintermann *Department of Genetics and Evolution, University of Geneva, Geneva, Switzerland.
Christopher C Bolt *School of Life Sciences, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
M Brent Hawkins *Department of Genetics, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-5164-2893
Guillaume ValentinSchool of Life Sciences, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.ORCID 0000-0003-4596-6282
Lucille Lopez-DelisleSchool of Life Sciences, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.ORCID 0000-0002-1964-4960
Madeline M RyanDepartment of Genetics, Harvard Medical School, Boston, MA, USA.
Sandra GittoDepartment of Genetics and Evolution, University of Geneva, Geneva, Switzerland.
Paula Barrera GómezSchool of Life Sciences, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
Bénédicte MascrezDepartment of Genetics and Evolution, University of Geneva, Geneva, Switzerland.
Thomas A MansourDepartment of Genetics, Rutgers University, New Brunswick, NJ, USA.
Tetsuya NakamuraDepartment of Genetics, Rutgers University, New Brunswick, NJ, USA.
Matthew P HarrisDepartment of Genetics, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-7201-4693
Neil H ShubinDepartment of Organismal Biology and Anatomy, University of Chicago, Chicago, IL, USA.ORCID 0000-0002-7424-0475
Denis DubouleDepartment of Genetics and Evolution, University of Geneva, Geneva, Switzerland. Denis.duboule@college-de-france.fr.ORCID 0000-0001-9961-2960

Funding

A novel role for Wasl signaling in the regulation of skeletal patterningR01HD112906 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI Matthew P Harris · 2023 to 2026
$2.1M
EPFL, University of Geneva, Swiss National Research FundEuropean Research CouncilNICHD NIH HHS R01 HD112906
6 · The paper itself

Abstract

The fin-to-limb transition in vertebrate evolution has been central to the study of how development underlies evolutionary change. In this context, the functional analysis of Hox gene regulation to infer evolutionary trajectories has been critical to explain the origin of new features. In tetrapods, the transcription of Hoxd genes in developing digits depends on a set of enhancers forming a large regulatory landscape

Indexed as

Biological EvolutionCloacaExtremitiesGene Expression Regulation, DevelopmentalZebrafishAnimal FinsAnimalsChromatinEnhancer Elements, GeneticFemaleGenes, HomeoboxHomeodomain ProteinsMaleMiceZebrafish ProteinsChromatinhomeobox protein HOXA13Homeodomain ProteinsZebrafish Proteins

Identifiers

PMID40963014
PMCPMC12675288

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.