Evidence map›Paper›PMID 40963044›Full record

ArticleGeroScience2026

Identifying novel modifiable risk factors for ischemic stroke through phenome-wide association study and Mendelian randomization analyses in a large-scale prospective cohort.

Siyu Wu, Jialin Li, Xinyue Zhao, Jincheng Li, Shuaizhou Chen, Chengtong Zhang, Chen Suo, Yingzhe Wang, Xingdong Chen, Mei Cui and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in GeroScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Siyu WuHuman Phenome Institute, Research and Innovation Center, Shanghai Pudong Hospital, Zhangjiang Fudan International Innovation Center, Fudan University, 2005 Songhu Rd, Shanghai, 200433, China.
Jialin LiHuman Phenome Institute, Research and Innovation Center, Shanghai Pudong Hospital, Zhangjiang Fudan International Innovation Center, Fudan University, 2005 Songhu Rd, Shanghai, 200433, China.
Xinyue ZhaoDepartment of Neurology, Huashan Hospital, Fudan University, No. 12 Middle Wulumuqi Road, Shanghai, 200040, China.
Jincheng LiHuman Phenome Institute, Research and Innovation Center, Shanghai Pudong Hospital, Zhangjiang Fudan International Innovation Center, Fudan University, 2005 Songhu Rd, Shanghai, 200433, China.
Shuaizhou ChenFudan University Taizhou Institute of Health Sciences, Taizhou, 225326, Jiangsu, China.
Chengtong ZhangHigh School Affiliated to University of Shanghai for Science and Technology, Shanghai, 200093, China.
Chen SuoFudan University Taizhou Institute of Health Sciences, Taizhou, 225326, Jiangsu, China.
Yingzhe WangDepartment of Neurology, Huashan Hospital, Fudan University, No. 12 Middle Wulumuqi Road, Shanghai, 200040, China.
Xingdong ChenFudan University Taizhou Institute of Health Sciences, Taizhou, 225326, Jiangsu, China.
Mei CuiDepartment of Neurology, Huashan Hospital, Fudan University, No. 12 Middle Wulumuqi Road, Shanghai, 200040, China. cuimei@fudan.edu.cn.
Qiuhong ManDepartment of Laboratory Medicine, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, 1279 Sanmen Rd, Shanghai, 200434, China. manqiuhong307@163.com.
Yanfeng JiangHuman Phenome Institute, Research and Innovation Center, Shanghai Pudong Hospital, Zhangjiang Fudan International Innovation Center, Fudan University, 2005 Songhu Rd, Shanghai, 200433, China. yanfengjiang@fudan.edu.cn.ORCID http://orcid.org/0000-0003-4976-6333

Funding

National Key Research and Development program of China 2023YFC3606300National Natural Science Foundation of China 82373658Science and Technology Innovation 2030 Major Projects 2022ZD0211600
6 · The paper itself

Abstract

Despite extensive research, significant uncertainty remains regarding the associations between various risk factors and ischemic stroke (IS). This study aimed to systematically identify and validate a broad range of potential modifiable risk factors for IS. Utilizing genetic and phenotypic data from the UK Biobank (UKB; N = 418,236), we conducted a phenome-wide association study (PheWAS) and Cox regression analysis to identify modifiable factors across sociodemographics, physical measures, lifestyles, medical history, mental health, and biological assays associated with both polygenic risk scores for IS (IS-PRS) and incident IS. To assess potential causal relationships, two-sample Mendelian randomization (MR) analysis was further performed. Among the 1,023 modifiable factors examined, 145 were significantly associated with both IS-PRS and incident IS. Notably, better lung function and more computer use were associated with decreased IS risk, whereas more summer outdoor exposure, sleep-related factors, mental health factor, and facial ageing were linked to increased IS risk. The strongest association was observed for pneumonitis due to solids and liquids, with a hazard ratio (HR) and 95% confidence interval (CI) of 7.65 (7.06- 8.28). MR analysis provided further causal evidence supporting 31 of the identified risk factors and confirmed the casual associations of worse lung function, greater summer outdoor exposure and longer daytime napping with increased IS risk. The study comprehensively identified a wide range of novel modifiable risk factors for IS, including physical, lifestyle, and mental health indicators. These findings may contribute to the development of more targeted and effective prevention strategies for IS.

Indexed as

Ischemic StrokeMendelian Randomization AnalysisAgedFemaleGenetic Risk ScoreGenome-Wide Association StudyHumansMaleMiddle AgedPhenomicsPhenotypeProspective StudiesRisk FactorsUK BiobankUnited KingdomIschemic strokeMendelian randomization analysisPhenome-wide association studyProspective studyUK Biobank

Identifiers

PMID40963044
PMCPMC13356251

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.