Evidence map›Paper›PMID 40963403›Full record

ReviewAnnals of medicine2025

Gut microbiota, circadian rhythms and their interactions: implications for the pathogenesis and treatment of depression.

Dongru Du, Yanling Yuan, Xuan Guan, Qinglian Xie, Xueli Sun, Zaiquan Dong

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Annals of medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Dongru DuWest China School of Medicine, Sichuan University, Chengdu, People's Republic of China.
Yanling YuanDepartment of Pharmacy, West China Hospital, Sichuan University, Chengdu, People's Republic of China.
Xuan GuanChengdu Medical College, Chengdu, People's Republic of China.
Qinglian XieDepartment of Outpatient, West China Hospital of Sichuan University, Chengdu, People's Republic of China.
Xueli SunMental Health Center, West China Hospital, Sichuan University, Chengdu, People's Republic of China.
Zaiquan DongMental Health Center, West China Hospital, Sichuan University, Chengdu, People's Republic of China.ORCID 0000-0003-0226-239X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDepression is a complex and widespread mental illness that remains poorly understood in terms of pathogenesis and treatment. Recent research has highlighted the intricate connections between gut microbiota and circadian rhythms and indicated that they may serve as significant factors associated with depression. DISCUSSION: The gut microbiota and its metabolites may affect circadian rhythms

conclusionBy focusing on this emerging area of study, this review reveals promising new developments in the pathogenesis and treatment of depression, emphasizing the novel concept that balancing our internal microbiome and body clock could be key to effectively managing this condition.

Indexed as

Circadian RhythmDepressionGastrointestinal MicrobiomeAnimalsHumansVagus Nervebidirectional interactioncircadian rhythmDepressiongut microbiotatreatment innovation

Identifiers

PMID40963403
PMCPMC12447470

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.