Evidence map›Paper›PMID 40963743›Full record

ArticlemedRxiv : the preprint server for health sciences2025

β

Ian A Carroll, Dobromir Slavov, Eric R Jonas, Wayne A Minobe, Lori A Walker, Amrut V Ambardekar, Timothy A McKinsey, Ammon D Knaupp, Donghwa Kim, Stephen B Liggett and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ian A CarrollDepartment of Medicine (Cardiology) University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Dobromir SlavovDepartment of Medicine (Cardiology) University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Eric R JonasDepartment of Medicine (Cardiology) University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Wayne A MinobeDepartment of Medicine (Cardiology) University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Lori A WalkerDepartment of Medicine (Cardiology) University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Amrut V AmbardekarDepartment of Medicine (Cardiology) University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Timothy A McKinseyDepartment of Medicine (Cardiology) University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Ammon D KnauppBYU Genomic and Bioinformatic Center, Provo UT 84602, USA.
Donghwa KimDepartment of Medicine and Center for Personalized Medicine, University of South Florida Morsani College of Medicine, Tampa, FL 33612, USA.
Stephen B LiggettGenvara Biopharma, Westminster, CO 80021 USA.
Michael R BristowDepartment of Medicine (Cardiology) University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.ORCID 0000-0002-8860-4698

Funding

PKCa Signaling Regulates Contractility and Heart FailureP50HL077101 · NHLBI · UNIVERSITY OF CINCINNATI · PI KRANIAS, EVANGELIA G · 2005 to 2009
$19.1M
VENTRICULAR MYOSIN LIGHT CHAIN 2 FUNCTION IN NORMAL AND FAILING HEARTSP50HL052318 · NHLBI · UNIVERSITY OF CINCINNATI · PI DORN, GERALD W. · 1995 to 2004
$8.8M
Genetic-Adrenergic Interactions in Myocardial FailureR01HL048013 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI BRISTOW, MICHAEL R. · 1993 to 2007
$4.5M
Basis of Variability of Lung GPCR SignalingR01HL071609 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI LIGGETT, STEPHEN B · 2003 to 2013
$3.7M
NHLBI NIH HHS P50 HL052318NHLBI NIH HHS P50 HL077101NHLBI NIH HHS R01 HL048013NHLBI NIH HHS R01 HL071609
6 · The paper itself

Abstract

Background: Methods: In two heart failure (HF) clinical trial genetic substudies we investigated effects of internalizing vs. internalization-resistant Results: In subjects with ≥3 internalizing Conclusions: 1) Both β

Indexed as

Beta Adrenergic ReceptorsBiased LigandsHaplotypesHeart FailureMAP Kinase ERK1/2PharmacogeneticsRacial Genetic VariationSingle Nucleotide Polymorphisms

Identifiers

PMID40963743
PMCPMC12440051

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.