Evidence map›Paper›PMID 40963744›Full record

ArticlemedRxiv : the preprint server for health sciences2025

No Evidence for Genetic Role of the Tumor Necrosis Factor Pathway in Parkinson's Disease.

Morvarid Ghamgosar Shahkhali, Lang Liu, Emma N Somerville, Alastair J Noyce, Ziv Gan-Or, Konstantin Senkevich

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Morvarid Ghamgosar ShahkhaliThe Neuro (Montreal Neurological Institute-Hospital), McGill University, Montreal, QC, Canada.
Lang LiuThe Neuro (Montreal Neurological Institute-Hospital), McGill University, Montreal, QC, Canada.
Emma N SomervilleThe Neuro (Montreal Neurological Institute-Hospital), McGill University, Montreal, QC, Canada.
Alastair J NoyceCentre for Preventive Neurology, Wolfson Institute of Population Health, Queen Mary University of London, London, UK.
Ziv Gan-OrThe Neuro (Montreal Neurological Institute-Hospital), McGill University, Montreal, QC, Canada.
Konstantin SenkevichThe Neuro (Montreal Neurological Institute-Hospital), McGill University, Montreal, QC, Canada.

Funding

Genetic characterization of atypical parkinsonismZIANS003154 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI SCHOLZ, SONJA · 2016 to 2025
$15.4M
Genome sequencing of Lewy Body Dementia and Frontotemporal Dementia: a public resource for the study of Alzheimers disease and related dementiasZIAAG000935 · NIA · NATIONAL INSTITUTE ON AGING · PI TRAYNOR, BRYAN · 2017 to 2025
$771k
Intramural NIH HHS ZIA AG000935Intramural NIH HHS ZIA NS003154
6 · The paper itself

Abstract

Tumor necrosis factor (TNF) inhibition is under investigation as a therapeutic strategy for Parkinson's disease (PD) and REM sleep behavior disorder (RBD), yet supporting genetic evidence is limited. We used Summary-data-based Mendelian Randomization (SMR) to test whether expression level of ten TNF-related genes were causally linked to PD risk, PD progression, or RBD risk. We also analyzed associations between common and rare variants in these genes, and performed pathway specific polygenic risk score analysis, with PD. Overall, our findings do not support a genetic link between the TNF signaling and PD or RBD, arguing against this pathway as a genetically validated therapeutic target.

Identifiers

PMID40963744
PMCPMC12440034

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.