Evidence map›Paper›PMID 40963758›Full record

ArticlemedRxiv : the preprint server for health sciences2025

Eight decades of follow-up link life course exposures to proteomic organ ageing and longevity.

James W Groves, Veronica Augustina Bot, Daisy Yi Ding, Jennifer Nicholas, Amelia Farinas, Hamilton See-Oh, Sarah-Naomi James, Andrew Wong, Dylan M Williams, Josh King-Robson and 4 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

James W GrovesDementia Research Centre, UCL Queen Square Institute of Neurology, London, UK.
Veronica Augustina BotWu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USA.
Daisy Yi DingWu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USA.
Jennifer NicholasDementia Research Centre, UCL Queen Square Institute of Neurology, London, UK.
Amelia FarinasWu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USA.
Hamilton See-OhWu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USA.
Sarah-Naomi JamesMRC Unit for Lifelong Health and Ageing, University College London, London, UK.
Andrew WongMRC Unit for Lifelong Health and Ageing, University College London, London, UK.
Dylan M WilliamsMRC Unit for Lifelong Health and Ageing, University College London, London, UK.
Josh King-RobsonDementia Research Centre, UCL Queen Square Institute of Neurology, London, UK.
Nishi ChaturvediMRC Unit for Lifelong Health and Ageing, University College London, London, UK.
Marcus RichardsMRC Unit for Lifelong Health and Ageing, University College London, London, UK.
Tony Wyss-CorayWu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USA.
Jonathan M SchottDementia Research Centre, UCL Queen Square Institute of Neurology, London, UK.

Funding

Training Program in Basic NeuroscienceT32MH020016 · NIMH · STANFORD UNIVERSITY · PI Justin L Gardner, Merritt C Maduke · 1997 to 2026
$16.2M
Molecular signature of parabiosisR01AG072255 · NIA · STANFORD UNIVERSITY · PI WYSS-CORAY, TONY · 2021 to 2025
$2.4M
NIA NIH HHS R01 AG072255NIMH NIH HHS T32 MH020016
6 · The paper itself

Abstract

The pace of organ ageing varies substantially between individuals, yet drivers of variability remain poorly understood. This gap is critical, given only 20-30% of longevity is genetically inherited

Identifiers

PMID40963758
PMCPMC12440047

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.