Evidence map›Paper›PMID 40964007›Full record

ArticleResearch square2025

Exploring the relationship between methylation of the cortisol receptor genes and brain and cognitive outcomes in individuals with elevated amyloid-β.

Tenielle Porter, Ayeisha Milligan Armstrong, Lidija Milicic, Michael Vacher, Shane Fernandez, Eleanor O'Brien, Vincent Doré, Pierrick Bourgeat, Rosita Shishegar, Ying Xia and 7 more

Abstract readPreprint
In one paragraph

Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Tenielle PorterEdith Cowan University.ORCID 0000-0002-7887-6622
Ayeisha Milligan ArmstrongORCID 0000-0001-6749-6184
Lidija MilicicNational Center for Posttraumatic Stress Disorder.
Michael VacherEdith Cowan University.
Shane Fernandez
Eleanor O'BrienEdith Cowan University.ORCID 0000-0001-5145-7340
Vincent DoréAustin Health.ORCID 0000-0002-8051-0558
Rosita Shishegar
Ying Xia
Christopher RoweAustin Health.ORCID 0000-0003-3910-2453
Victor Villemagne
Paul MaruffMHRI, University of Melbourne, Melbourne Australia/CogState, Melbourne.ORCID 0000-0002-6947-9537
Colin Masters4The Florey Institute of Neuroscience and Mental Health, The University of Melbourne.
Giuseppe VerdileMcCusker Alzheimer's Research Foundation.
Simon LawsEdith Cowan University.ORCID 0000-0002-4355-7082
David Groth

Funding

Project 1U19AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI MONICA G. RIVERA-MINDT · 2016 to 2026
$226.7M
NIA NIH HHS U19 AG024904
6 · The paper itself

Abstract

Chronic stress has been implicated as a risk factor for Alzheimer's disease (AD), although the molecular pathways linking stress with AD are poorly understood. In this study, relationships between differential methylation of the cortisol receptor genes, the glucocorticoid and mineralocorticoid receptors (

Identifiers

PMID40964007
PMCPMC12440088

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.