Analysis of microbiotas between traumatic and ulcerative wound: insights into challenges of current wounds managements.

Objective: Wounds frequently occur during daily activities and clinical treatments, exerting substantial impacts on patients' health status and recovery processes. Methods: All the patients were enrolled for this analysis from January 2022 to December 2022 who received wound management at Wound Care Center, West China Hospital, Sichuan University, which was a single center, prospectively designed observational study. In this investigation, microbial samples were collected from 106 traumatic wounds and 157 ulcerative wounds and analysed by 16S rRNA gene sequencing. Results: The findings revealed distinct differences in the microbial composition and function between traumatic and ulcerative wounds. Specifically, ulcerative wounds exhibited significantly higher abundances of infection- and pro-inflammation-related microbes, such as Conclusion: Comparative analyses of the microbial communities in wounds reveled that traumatic wounds, especially non-postoperative wounds, were more easily to heal, however, the ulcerative wounds, especially the non-venous wounds, were more difficult to heal. These results suggest that different types of wounds harbor distinct microbial compositions, providing valuable data to inform improved clinical wound management strategies.