ArticleSichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition2025
[Effect of High-Altitude Hypoxia on the Pharmacokinetics and Brain Distribution of Phenytoin Sodium in Epileptic Rats].
Article in Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Effect of high altitude on the pharmacokinetics and pharmacodynamics of valproate in epileptic rats.Frontiers in pharmacology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: To investigate the effects of high-altitude hypoxic environment on the pharmacokinetic characteristics and brain tissue distribution of phenytoin sodium in epileptic rats. Methods: A total of 70 male SPF-grade Wistar rats aged 2 months and weighing (200 ± 20) g were used in the study. An epilepsy model was induced in the rats using the lithium chloride-pilocarpine method. The successfully modeled rats were randomly assigned to a normoxic treatment group and a high-altitude hypoxic treatment group. Phenytoin sodium was administered via intragastric gavage at a dose of 50 mg/kg in both groups. Blood samples were collected from the orbital venous plexus before treatment and 0.5, 1, 2, 3, 4, 6, 8, 10, and 24 h post treatment. The animals were euthanized after the final blood collection, and samples of the liver and the whole brain tissue were collected. In the brain tissue distribution experiment, brain tissue samples were collected at 0.5, 1, 2, and 4 h after drug administration. The concentration of phenytoin sodium in rat plasma and brain tissue was determined by liquid chromatography-tandem mass spectrometry (LC-MS/MS), and the pharmacokinetic parameters were calculated using WinNolin 8.1 software. The expression levels of CYP2C9 in liver tissue and those of P-gp in brain tissue of epileptic rats were determined by Western blot. Results: Compared with those in the normoxia group, the peak concentration, peak time, and half-life of phenytoin sodium in the high-altitude hypoxia group were significantly decreased by 46.0%, 42.3%, and 55.5%, respectively (all Conclusion: The hypoxic environment at high altitudes can promote the metabolism of phenytoin sodium, reduce its absorption efficiency, and change the characteristics its distribution in the brain, which may be related to the up-regulation of the expression of CYP2C9 in the liver and that of P-gp in the brain.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.