Evidence map›Paper›PMID 40964105›Full record

ArticleSichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition2025

[Diabetic Nephropathy Treatment by Zn Supplementation in a Murine Model of Type 1 Diabetes Mellitus: Potential Role of Nrf2 Signaling Pathway].

Lianhong Xu, Weixia Sun, Wei Liu, Yanbo Li

Abstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Lianhong Xu（ 130021） Department of Nephrology, The First Hospital of Jilin University, Changchun 130021, China.ORCID 0009-0004-4658-5953
Weixia Sun（ 130021） Department of Nephrology, The First Hospital of Jilin University, Changchun 130021, China.
Wei Liu（ 130021） Department of Nephrology, The First Hospital of Jilin University, Changchun 130021, China.
Yanbo Li（ 130021） Department of Nephrology, The First Hospital of Jilin University, Changchun 130021, China.ORCID 0009-0006-7815

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To evaluate the renoprotective effects of zinc (Zn) supplementation in diabetes kidney disease (DKD) and to explore its impact on the nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway. Methods: A total of 12 male OVE26 mice (spontaneous type 1 diabetes mellitus mice) aged 3 months and weighing approximately 24-27 g were selected and randomly assigned to a diabetes mellitus (DM) group and a zinc-treated DM (DM/Zn) group ( Results: 1) Compared to the Ctrl group, the urinary protein secretion levels of mice in the DM group exhibited progressive increase. After 3 months of zinc supplementation treatment, the urinary protein secretion levels of mice in the DM/Zn group decreased Compared to that of mice in the DM group, and the difference was statistically significant ( Conclusions: Zn supplementation has therapeutic effects on DKD and mitigates T1DM-induced renal dysfunction and oxidative injury in mice, which may be associated with the activation of the Nrf2 antioxidant signaling pathway.

Indexed as

Diabetes Mellitus, Type 1Diabetic NephropathiesNF-E2-Related Factor 2Signal TransductionZincAnimalsConnective Tissue Growth FactorDiabetes Mellitus, ExperimentalDietary SupplementsDisease Models, AnimalKidneyMaleMiceTransforming Growth Factor beta1Connective Tissue Growth FactorNfe2l2 protein, mouseNF-E2-Related Factor 2Transforming Growth Factor beta1ZincAntioxidant substanceDiabetic nephropathyNrf2Zn

Identifiers

PMID40964105
PMCPMC12439658

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.