ArticleSichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition2025
[Oxidative Stress Induced by High Glucose Aggravates Immunosuppression in Diabetes Mellitus by Promoting Effector T Cell Apoptosis and Regulatory T Cell Differentiation].
Article in Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
Objective: To explore the regulatory mechanisms underlying the increased proportion of CD4 Methods: Wild-type C57BL/6 mice aged 6 to 8 weeks were randomly assigned to two groups, the experimental and the control groups ( Results: Late-stage T1D and T2D mice with poorly-managed blood glucose exhibited increased peripheral CD4 Conclusion: Sustained hyperglycemic internal environment in poorly-controlled diabetic mice causes high level of ROS production in Teff cells by inducing oxidative stress, which leads to increased apoptosis of Teff cells, promotes the differentiation of Treg cells by activating TGF-β, and ultimately leads to exacerbated immunosuppressive environment in the late stages of DM. Inhibiting the high level of ROS in late-stage diabetic patients may be conducive to mitigating Teff apoptosis and increasing the frequencies of Treg cells, and may offer new perspectives for improving hyperglycemia-induced immunosuppression and secondary infections in the late stage of DM.
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