ReviewFrontiers in reproductive health2025
Polycystic ovary syndrome and organochlorine pesticides: exploring potential links and mechanisms.
Review in Frontiers in reproductive health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- The Role of Antioxidants in the Management of Polycystic Ovary Syndrome.Antioxidants (Basel, Switzerland) · 2026Review
- Lifestyle factors for polycystic ovary syndrome: a case-control study.Journal of ovarian research · 2026Article
- Exploring the comorbidity of type 2 diabetes mellitus and polycystic ovary syndrome: treatment with traditional Chinese medicine.Frontiers in medicine · 2026Review
- Health Implications of Shift Work in Airline Pilots and Cabin Crew: A Narrative Review and Pilot Study Findings.Nutrients · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder among women, characterized by metabolic abnormalities and infertility. Despite its high prevalence, the etiology and pathogenesis of PCOS remain poorly understood. Emerging evidence suggests that persistent organic pollutants (POPs), known for their detrimental effects on the endocrine and reproductive systems, may play a role in the development and progression of PCOS. Among POPs, organochlorine pesticides (OCPs) are particularly widespread and pose significant health risks. This review examines the potential of OCPs as an environmental factor in the development and progression of PCOS. It highlights the mechanisms through which OCPs may disrupt the hypothalamic-pituitary-ovarian (HPO) axis and impair hormonal regulation, contributing to the onset and exacerbation of PCOS. Evidence links OCPs to insulin resistance, obesity, and type 2 diabetes mellitus. These disruptions may occur via pathways involving hypothyroidism or altered adrenal androgen secretion. While current evidence supports a plausible connection between OCP exposure and PCOS, significant gaps and inconsistencies in the data warrant further investigation. Elucidating the precise mechanisms underlying these associations is crucial for developing targeted prevention and intervention strategies.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.