ReviewJournal of inflammation research2025
The Bidirectional Role of Obesity and Aging in the Pathogenesis of Osteoarthritis: Molecular Mechanisms, Epigenetic Insights, and Therapeutic Implications.
Review in Journal of inflammation research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Dual-modal antioxidant and epigenetic synergy attenuates the self-perpetuating senescence cycle in osteoarthritis.Bioactive materials · 2027Article
- REJENERAInflammopharmacology · 2026Article
- Patient Age Is Not a Determinant of 12-Month Pain Response After Autologous Adipose-Derived Stromal Vascular Fraction Injection for Knee Osteoarthritis.Medicina (Kaunas, Lithuania) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Osteoarthritis (OA) is a major global contributor to pain, disability, and socioeconomic burden. With the increasing prevalence of obesity and an aging population, the incidence of OA continues to rise. This review explores the bidirectional relationship between obesity and aging in the pathogenesis of OA, focusing on the underlying molecular mechanisms. Obesity contributes to aging by inducing oxidative stress, chronic inflammation, and metabolic dysregulation, thereby promoting OA development and progression. Conversely, the accumulation of senescent cells with age exacerbates obesity-induced inflammation and metabolic dysfunction by secreting pro-inflammatory cytokines and bioactive molecules. Epigenetic changes, including DNA methylation, histone modifications, and the regulation of non-coding RNAs, play pivotal roles in modulating these interactions, further influencing OA progression. The review also discusses current and emerging therapeutic strategies targeting the obesity-aging-OA axis, highlighting the potential of epigenetic interventions and novel anti-inflammatory treatments. A comprehensive understanding of the molecular interplay between obesity and aging in OA is essential for developing more effective prevention and treatment strategies. Future research should prioritize the in-depth exploration of epigenetic mechanisms, coupled with technological innovation, standardized education and training, quality control, and multidisciplinary collaboration. Targeted strategies and interventions are essential to effectively prevent and manage obesity- and OA-related diseases.
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Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.