ArticlebioRxiv : the preprint server for biology2025
Directed connectomes across species reveal conserved and divergent pathways of neural signaling.
Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Understanding how brain networks support cognition requires knowing not only which regions are connected but the direction in which neuronal signals propagate. However, directed connectivity cannot be measured non-invasively in primates or humans, limiting systems-level inference. Here we integrate projection polarity from ~1,200 mouse viral tracing experiments with species-specific diffusion MRI tractography to construct directed connectomes across mouse, marmoset, macaque, and human. Using a common cross-species atlas, we developed a path efficiency metric that balances projection strength against axonal length and applied shortest-path algorithms to quantify directional influence. This framework revealed conserved and divergent organization: the entorhinal-hippocampal projection was the most efficient in all species; humans showed strengthened anterior insula-superior temporal pathways; macaques exhibited peak inferior temporal outflows; and marmosets maintained disproportionately strong olfactory influence. These results provide a scalable and ethically feasible approach for modeling directed neuronal signaling across species.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.