In one paragraphArticle in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
20 authors.
Prashanthi RavichandranDepartment of Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, MD, 21218, USA.ORCID 0000-0002-9364-175X Svitlana V BachLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA.ORCID 0000-0003-1134-9585 Robert A PhillipsLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA.ORCID 0000-0003-3560-4747 Madeline R ValentineLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA.ORCID 0000-0001-6078-2794 Nicholas J EaglesLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA.ORCID 0000-0002-9808-5254 Ishbel Del RosarioLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA.ORCID 0000-0001-6225-0660 Ryan A MillerLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA.ORCID 0000-0003-3477-7443 Heena R DivechaLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA.ORCID 0000-0002-1959-0675 Madhavi TippaniLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA.ORCID 0000-0002-6465-6418 Kelsey D MontgomeryLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA.ORCID 0000-0001-8420-0138 Joel E KleinmanLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA.ORCID 0000-0002-4210-6052 Shizhong HanLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA.ORCID 0000-0002-5114-6742 Stephanie C PageLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA.ORCID 0000-0002-1951-7398 Thomas M HydeLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA.ORCID 0000-0002-8746-3037 Leonardo Collado-TorresLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA.ORCID 0000-0003-2140-308X Alexis BattleDepartment of Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, MD, 21218, USA.ORCID 0000-0002-5287-627X Keri MartinowichLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA.ORCID 0000-0002-5237-0789 Stephanie C HicksDepartment of Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, MD, 21218, USA.ORCID 0000-0002-7858-0231 Kristen R MaynardLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA.ORCID 0000-0003-0031-8468 Funding
Registration of spatial gene expression in key nodes of reward-related circuitry in the human brainR01DA053581 · NIDA · LIEBER INSTITUTE, INC. · PI MARTINOWICH, KERI · 2021 to 2025
$3.7MModeling the dynamicimpact of rare and common genetic variation on gene expression anddiseaseR35GM139580 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI BATTLE, ALEXIS · 2021 to 2025
$3.1MIdentifying a functional role for transcriptionally distinct, BLA-activated LS ensembles in social behaviorsF32MH139150 · NIMH · LIEBER INSTITUTE, INC. · PI Robert Phillips · 2024 to 2026
$161kNIDA NIH HHS R01 DA053581NIGMS NIH HHS R35 GM139580NIMH NIH HHS F32 MH139150
6 · The paper itselfAbstract
The nucleus accumbens (NAc) is a key component of the mesolimbic dopamine system that critically regulates many behaviors related to reward and motivation. The NAc is implicated in several neuropsychiatric disorders, including major depressive disorder, schizophrenia, and substance use disorders. Rodent studies have identified spatial organization of heterogeneous medium spiny neuron (MSN) subtypes across the NAc core and shell, but the extent to which this cellular diversity and spatial organization is conserved in the human brain remains unclear. Here, we generated a spatiomolecular atlas of NAc cell types and spatial domains by integrating spatial transcriptomics and single-nucleus RNA sequencing data from postmortem NAc tissue from 10 neurotypical adult donors. We identified 20 transcriptionally unique cell populations and 8 spatial domains, including specialized D1 islands composed of distinct dopamine receptor 1 (DRD1) MSN subtypes, which were enriched for
Indexed as
nucleus accumbenspostmortem human brainsingle-nucleus RNA-sequencingspatially-resolved transcriptomics
Identifiers
PMID40964296
PMCPMC12439884
What Socratic holds
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LicenceCC BY
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