ArticleFrontiers in nutrition2025
Association between red cell distribution width to albumin ratio and clinical outcomes in elderly patients with sepsis: a cohort study.
Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- The prognostic value of red cell distribution width-to-albumin ratio for 28-day mortality in sepsis patients: a multicenter analysis based on the eICU Collaborative Research Database.Frontiers in medicine · 2026Article
- Dynamic albumin-to-RDW trajectories for time-dependent risk stratification in acute brain injury.Frontiers in nutrition · 2026Article
- Admission red cell distribution width-to-albumin ratio and risk of neonatal pneumonia or culture-proven sepsis in preterm infants: a retrospective cohort study.Frontiers in pediatrics · 2026Article
- Red cell distribution width to albumin ratio predicts short-term mortality in urosepsis: a dual-cohort study.Frontiers in nutrition · 2026Article
- Red Cell Distribution Width-to-Albumin Ratio as a Predictor of Preeclampsia in Advanced Maternal Age: A Retrospective Cohort Study.International journal of women's health · 2026Article
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Abstract
Background: This study investigates the association between red cell distribution width to albumin ratio (RAR) and clinical outcomes in elderly sepsis patients. Methods: This study investigates the association between red cell distribution width to albumin ratio (RAR) and clinical outcomes in elderly sepsis patients. Methods: Using the eICU-CRD (2014-2015), 5,976 sepsis patients aged≥60 years were stratified into RAR quartiles at ICU admission: Q1 (≤5.28), Q2 (5.29-6.37), Q3 (6.38-7.87), and Q4 (7.88-15.0), with Q1 as the reference category. The primary outcome was 28-day hospital mortality, while secondary outcomes included ICU mortality, 90-day hospital mortality, and lengths of ICU and hospital stays. Multivariable regression analysis and spline curves from the generalized additive model were applied to assess the association between RAR and clinical outcomes. Kaplan-Meier survival analysis illustrated cumulative hospital mortality across RAR quartiles. Results: The 28-day hospital, ICU, and 90-day hospital mortality were 17.4, 10.9, 17.8%, respectively, with ICU and hospital stays of 2.9 (1.8-5.1) and 7.1 (4.6-11.7) days. Compared to Q1, Q4 exhibited significantly increased risks of 28-day hospital mortality (adjusted odds ratio [OR]: 2.95, 95% confidence interval [CI]: 2.28-3.80), ICU mortality (adjusted OR: 2.06, 95% CI: 1.52-2.78), 90-day hospital mortality (adjusted OR: 3.03, 95% CI: 2.35-3.90), and prolonged ICU ( Conclusion: Elevated baseline RAR is independently associated with adverse clinical outcomes in elderly sepsis patients, suggesting it may be a valuable tool for early risk stratification and personalized therapeutic interventions.
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