Evidence map›Paper›PMID 40964812›Full record

ReviewObesity (Silver Spring, Md.)2025

Precision Prevention, Diagnostics, and Treatment of Obesity: Pipedream or Reality?

Emily K Woolf, Hanim E Diktas, Andres Acosta, John W Apolzan, Jamy D Ard, Kristen E Boyle, Jack A Gilbert, Peter T Katzmarzyk, Paul J Laurienti, Tim Lobstein and 10 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Obesity (Silver Spring, Md.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Emily K WoolfPennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana, USA.ORCID https://orcid.org/0009-0007-1546-865X
Hanim E DiktasPennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana, USA.ORCID https://orcid.org/0000-0002-4603-3719
Andres AcostaDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA.ORCID https://orcid.org/0000-0003-2286-489X
John W ApolzanPennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana, USA.ORCID https://orcid.org/0000-0001-8492-7820
Jamy D ArdDepartment of Epidemiology and Prevention and Department of Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.ORCID https://orcid.org/0000-0002-1643-6795
Kristen E BoyleSection of Nutrition, Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.ORCID https://orcid.org/0000-0001-9689-3322
Jack A GilbertDepartment of Pediatrics and Scripps Institution of Oceanography, University of California San Diego, La Jolla, California, USA.
Peter T KatzmarzykPennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana, USA.ORCID https://orcid.org/0000-0002-9280-6022
Paul J LaurientiDepartment of Radiology, Wake Forest School of Medicine, Wake Forest University, Winston-Salem, North Carolina, USA.
Tim LobsteinWorld Obesity Federation, London, UK.
Holly L NicastroOffice of Nutrition Research, National Institutes of Health, Bethesda, Maryland, USA.
Jose M OrdovasJean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts, USA.
Suzanne PhelanDepartment of Kinesiology & Public Health, Center for Health Research, California Polytechnic State University, San Luis Obispo, California, USA.ORCID https://orcid.org/0000-0003-2260-0499
Leanne M RedmanPennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana, USA.ORCID https://orcid.org/0000-0002-7267-7374
Brian E RoeDepartment of Agricultural, Environmental & Development Economics, Ohio State University, USA.ORCID https://orcid.org/0000-0003-4228-2889
Donna H RyanPennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana, USA.
Jacqueline M StephensPennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana, USA.ORCID https://orcid.org/0000-0002-3796-9531
Deborah F TateDepartment of Nutrition and Health Behavior, Nutrition Research Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.ORCID https://orcid.org/0000-0002-4915-5308
Caroline M ApovianDivision of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0002-8029-1922
Corby K MartinPennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana, USA.ORCID https://orcid.org/0000-0002-8125-4015

Funding

Louisiana Clinical and Translational Science CenterU54GM104940 · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · 2025 to 2025
$3.9M
Pilot and Feasibility ProgramP30DK072476 · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · 2005 to 2025
$2.2M
Training in Obesity ResearchT32DK064584 · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · 2003 to 2025
$932k
Leveraging machine learning and EMA data to identify factors that predict children's energy intakeF32HD116537 · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · 2025 to 2025
$80k
Examining dietary and metabolomics patterns on cardiometabolic outcome variability in response to calorie restrictionF32HL176217 · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · 2025 to 2025
$80k
NHLBI NIH HHS F32 HL176217NICHD NIH HHS F32 HD116537NIDDK NIH HHS P30 DK072476NIDDK NIH HHS T32 DK064584NIGMS NIH HHS U54 GM104940Postdoctoral Fellowships T32 DK64584
6 · The paper itself

Abstract

Precision medicine approaches have gained attention for their potential to more effectively manage obesity by tailoring diagnosis and treatment strategies to individual characteristics, including genetic background, phenotypes, metabolic profiles, and environmental exposures. The current review evaluates the evidence for precision medicine in weight management by summarizing the proceedings of a Pennington Biomedical Scientific Symposium titled "Precision Prevention, Diagnostics, and Treatment of Obesity: Pipedream or Reality?" This review discusses the extent to which we can classify and predict obesity risk based on individual-level factors; whether we have the diagnostic capability to prospectively identify people who will benefit most from specific interventions; whether prospective trials demonstrate superior prevention and treatment of obesity when precision approaches are applied; and whether evidence is sufficient to guide policy decisions. Expert opinions were presented on the current evidence of precision medicine for obesity to collectively evaluate key barriers and opportunities for implementation of precision approaches in clinical and public health settings.

Indexed as

ObesityPrecision MedicineHumansRisk Factorsobesity managementobesity preventionprecision medicine

Identifiers

PMID40964812
PMCPMC12715877

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.