Evidence map›Paper›PMID 40965407›Full record

ArticleInvestigative ophthalmology & visual science2025

Absence of Glaucoma in Tg-MYOCY437H Mice of Diverse Genetic Backgrounds.

Nicholas G Tolman, Marina Simón, Felicia A Juarez, Chi Zhang, Zhivka I Hristova, Tionna B Ouellette, Michael A Sellarole, Wilhelmine N deVries, Christa Montgomery, Simon W M John

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Investigative ophthalmology & visual science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Nicholas G TolmanDepartment of Ophthalmology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, New York, United States.
Marina SimónDepartment of Ophthalmology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, New York, United States.
Felicia A JuarezDepartment of Ophthalmology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, New York, United States.
Chi ZhangDepartment of Ophthalmology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, New York, United States.
Zhivka I HristovaThe Jackson Laboratory, Bar Harbor, Maine, United States.
Tionna B OuelletteThe Jackson Laboratory, Bar Harbor, Maine, United States.
Michael A SellaroleThe Jackson Laboratory, Bar Harbor, Maine, United States.
Wilhelmine N deVriesThe Jackson Laboratory, Bar Harbor, Maine, United States.
Christa MontgomeryDepartment of Ophthalmology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, New York, United States.
Simon W M JohnDepartment of Ophthalmology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, New York, United States.

Funding

Instrumentation, Fabrication, and Design CoreP30EY019007 · NEI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Xin Zhang · 2010 to 2026
$12.9M
Factors Determining Intraocular Pressure and Glaucoma SusceptibilityR01EY011721 · NEI · JACKSON LABORATORY · PI JOHN, SIMON W · 2002 to 2018
$12.4M
Cell Death Pathways in Glaucomatous NeurodegenerationR01EY018606 · NEI · UNIVERSITY OF ROCHESTER · PI JOHN, SIMON W, LIBBY, RICHARD T · 2008 to 2023
$5.8M
Does VECAD at Schlemm canal cell-junctions determine IOP and glaucoma risk?R01EY032062 · NEI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI JOHN, SIMON W, KIZHATIL, KRISHNAKUMAR · 2021 to 2025
$3.5M
Models, mechanisms and treatment of LMX1B-induced glaucomaR01EY032507 · NEI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI JOHN, SIMON W · 2021 to 2024
$2.3M
FACTORS DETERMINING INTRAOCULAR PRESSURER29EY011721 · NEI · JACKSON LABORATORY · PI JOHN, SIMON W · 1997 to 2001
$227k
NEI NIH HHS P30 EY019007NEI NIH HHS R01 EY011721NEI NIH HHS R01 EY018606NEI NIH HHS R01 EY032062NEI NIH HHS R01 EY032507NEI NIH HHS R29 EY011721
6 · The paper itself

Abstract

Purpose: Mutations in the myocilin (MYOC) gene cause elevated intraocular pressure and glaucoma. To better understand the factors influencing susceptibility to glaucoma, we studied the MYOC mutation (MYOCY437H). Methods: We characterized ocular phenotypes in Tg-MYOCY437H mice on nine different mouse strain backgrounds. Results: No glaucoma-related phenotypes were observed. We detected neither elevated intraocular pressure (daytime readings) nor optic nerve degeneration differences between wild type (WT) and Tg-MYOCY437H mice. This included an absence of Tg-MYOCY437H-induced phenotypes on a mixed B6SJL background that best reflected the original publications with this strain. We confirmed that this result was not due to an absence of transgene expression in ocular tissues. Conclusions: Our data indicate undefined complexity and that the previously reported glaucoma phenotypes are not robust across all institutions and environments.

Indexed as

Cytoskeletal ProteinsEye ProteinsGlaucomaGlycoproteinsMutationAnimalsDisease Models, AnimalGenetic BackgroundIntraocular PressureMiceMice, Inbred C57BLMice, TransgenicMyocilinPhenotypeCytoskeletal ProteinsEye ProteinsGlycoproteinsMyocilin

Identifiers

PMID40965407
PMCPMC12449821

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.