Evidence map›Paper›PMID 40965683›Full record

SynthesisOral and maxillofacial surgery2025

Intra-articular injections in temporomandibular arthralgia: a systematic review.

Sanjay Chikkarasinakere Jogigowda, Shilpa Padar Shastry, Varusha Sharon Christopher, Karthikeya Patil, Ritu Basavarajappa, Vidya Gowdappa Doddawad, Deepa B V

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Oral and maxillofacial surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Prolotherapy for temporomandibular joint disorders: an updated comprehensive review.Journal of the Korean Association of Oral and Maxillofacial Surgeons · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sanjay Chikkarasinakere JogigowdaDepartment of Oral Medicine and Radiology, JSS Dental College and Hospital, JSS Academy of Higher Education and Research Mysuru, Karnataka, 570015, India.ORCID http://orcid.org/0000-0003-2830-1481
Shilpa Padar ShastryDepartment of Oral Medicine and Radiology, Vydehi Institute of Dental Sciences and Research Centre, Bengaluru, Karnataka, 560066, India.ORCID http://orcid.org/0000-0003-0595-4666
Varusha Sharon ChristopherDepartment of Oral Medicine and Radiology, JSS Dental College and Hospital, JSS Academy of Higher Education and Research Mysuru, Karnataka, 570015, India.ORCID http://orcid.org/0009-0009-2610-0951
Karthikeya PatilDepartment of Oral Medicine and Radiology, JSS Dental College and Hospital, JSS Academy of Higher Education and Research Mysuru, Karnataka, 570015, India. dr.karthikeyapatil@jssuni.edu.in.ORCID http://orcid.org/0000-0002-7941-2467
Ritu BasavarajappaDepartment of Oral Medicine and Radiology, JSS Dental College and Hospital, JSS Academy of Higher Education and Research Mysuru, Karnataka, 570015, India.ORCID http://orcid.org/0009-0002-7967-5248
Vidya Gowdappa DoddawadDepartment of Oral Pathology and Microbiology, JSS Dental College and Hospital, JSS Academy of Higher Education and Research Mysuru, Karnataka, 570015, India.ORCID http://orcid.org/0000-0001-5204-8178
Deepa B VDepartment of Oral and Maxillofacial Surgery, JSS Dental College and Hospital, JSS Academy of Higher Education and Research Mysuru, Karnataka, 570015, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis systematic review evaluates the effectiveness and safety of intra-articular injections for temporomandibular joint (TMJ) arthralgia in adults, comparing various injection types against alternative treatments or placebo.

methodsWe conducted a comprehensive literature search across Scopus and Pubmed from January 2015 to December 2024, including randomized controlled trials, prospective comparative clinical trials, and observational studies with control groups. Eligibility criteria required adult patients with clinically diagnosed TMJ arthralgia, various intra-articular injections, and outcome measures including pain reduction and jaw function improvement. The Cochrane Risk of Bias Tool (RoB 2) assessed methodological quality across included studies.

resultsThe review included seven high-quality studies with sample sizes ranging from 20 to 114 participants across multiple countries. All injection types-corticosteroids, hyaluronic acid, and platelet-rich plasma-demonstrated significant pain reduction and functional improvement within treatment groups. Between-group differences were often not statistically significant in high-quality randomized controlled trials. Specific advantages were noted: sodium hyaluronate may be more effective for reducing joint noises, while corticosteroids showed better short-term pain relief.

conclusionThe evidence supports intra-articular injections as effective treatment options for TMJ arthralgia, though no single intervention consistently outperformed others across all outcomes. Treatment selection should be individualized based on patient presentation and preferences. OTHER: This review was prospectively registered in PROSPERO (CRD42025632073) and received no external funding.

Indexed as

Adrenal Cortex HormonesArthralgiaHyaluronic AcidTemporomandibular Joint DisordersHumansInjections, Intra-ArticularPlatelet-Rich PlasmaRandomized Controlled Trials as TopicViscosupplementsAdrenal Cortex HormonesHyaluronic AcidViscosupplementsAdverse effectsIntra-articular injectionsSystematic reviewTemporomandibular joint disordersTreatment outcome

Identifiers

PMID40965683

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.