ArticleCNS neuroscience & therapeutics2025
Disrupted Brain Structure-Function Coupling and Its Mediating Effects on the Associations Between Cerebral Small Vessel Disease Burden and Cognitive Dysfunction.
Article in CNS neuroscience & therapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Magnetic Resonance Imaging-Defined Cerebral Small Vessel Disease Burden and Longitudinal Neuropsychiatric and Functional Recovery After Stroke: A Prospective Cohort Study.Neurology international · 2026Article
- Structure-Function Decoupling Across Cerebrovascular Diseases: A Convergent Network Phenotype Requiring Disease-Specific Interpretation.CNS neuroscience & therapeutics · 2026Article
- Functional-Structural Coupling: Brain Reorganization in Presbycusis Is Related to Cognitive Impairment.eNeuro · 2026Article
- Disrupted Brain Structure-Function Coupling and Its Mediating Effects on the Associations Between Cerebral Small Vessel Disease Burden and Cognitive Dysfunction.CNS neuroscience & therapeutics · 2025Article
- High-dose accelerated intermittent theta burst stimulation targeting the primary motor cortex for gait and cognitive functions in cerebral small vessel disease: a randomized controlled trial.Frontiers in neurologyArticle
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
aimsWe aimed to specify relationships among cerebral small vessel disease (CSVD) burden, cognitive dysfunction, and brain structure-function coupling changes.
methodsA total of 108 patients with mild CSVD burden (CSVD-m), 53 patients with severe CSVD burden (CSVD-s), and 76 healthy controls (HC) were included in this study. The ratio of regional homogeneity (ReHo) or amplitude of low-frequency fluctuation (ALFF) to gray matter volume (GMV) was calculated as an indicator of voxel-wise structure-function coupling.
resultsSignificantly decreased or increased ReHo-GMV and ALFF-GMV coupling values in patients with severe CSVD burden were primarily found in several brain regions, and the disrupted structure-function coupling in the right putamen mediated the relationship between CSVD burden and cognitive dysfunction.
conclusionsBrain structure-function coupling characterized by ReHo-GMV and ALFF-GMV mediated the cognitive dysfunction caused by CSVD and was an innovative and effective brain imaging indicator for exploring the association between CSVD burden and cognitive dysfunction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.