ReviewStem cell reviews and reports2025
Deciphering the Role of Long Non-coding RNAs in Neural Differentiation and Reprogramming.
Review in Stem cell reviews and reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Long non-coding RNAs (lncRNAs) have emerged as key regulators of neural differentiation and neurological diseases. Abundantly expressed in the central nervous system, lncRNAs play crucial roles in neural development by modulating transcriptional, epigenetic, and post-transcriptional processes. This review summarizes recent advances in understanding how lncRNAs regulate the differentiation of stem cells, including embryonic stem cells and neural stem cells, by interacting with transcription factors, chromatin regulators, and microRNAs. LncRNAs influence neurogenesis by determining the fate of neural progenitors, controlling the timing of differentiation, and balancing self-renewal. In addition to their role in neural differentiation, lncRNAs also play critical roles in various neurological diseases, such as Alzheimer's disease, Parkinson's disease, and glioblastoma, where their dysregulation contributes to neuroinflammation, synaptic dysfunction, and tumor progression. These findings highlight the potential of lncRNAs as diagnostic biomarkers and therapeutic targets for neurological disorders. Despite challenges in delivery and functional characterization, targeting disease-associated lncRNAs offers promise for regenerative medicine and precision treatments. A deeper understanding of lncRNA-mediated regulatory networks could lead to novel therapeutic strategies for neurodegenerative and neuro-oncological diseases.
Indexed as
Identifiers
40965813What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.